Gender in Face-Voice Integration

Healthy Clinical Trial

— Face-Voice  

Official title:

Neural Correlates of Multimodal Face/Voice Processing in a Gender Task.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03058133
• Other study ID #: 69HCL16_0674
• Status: Completed
• Phase: N/A
• Start date: May 20, 2016
• Est. completion date: May 28, 2018

Study information

• Verified date: August 2018
• Source: Hospices Civils de Lyon
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Bayesian models of perception represent a promising approach to describe information processing by the brain. Predictive coding hypothesizes a process in which top-down expectations are continuously compared across multiple hierarchical levels with bottom-up sensory inputs and the differences or error signals are propagated in a bottom-up direction. The investigators hypothesize that strong expectations, are best investigated in expert processes such as face and voice recognition in humans. Individuals in complex social systems need to extract socially relevant information in a fast and efficient manner; hence, the majority of humans constitute face, voice and gender experts. Nevertheless, linking such combined abilities to brain activity with regards to the predictive coding hypothesis has not been attempted.Our results suggest asymmetric contributions of visual and auditory signals to the gender classification task. This sensitive psychophysical procedure is implemented in a decoding approach using fMRI and multi-voxel pattern analysis (MVPA). The investigators plan to test whether cortical areas implicated in processing auditory and visual gender signals show similar asymmetries.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 38
• Est. completion date: May 28, 2018
• Est. primary completion date: May 28, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Healthy men and women, right-handed

• No neurological antecedent

• Signed informed consent

Exclusion Criteria:

• Pregnant women

• Volunteers with MRI contraindications: persons using a pacemaker or insulin pump, persons with a metallic prosthesis or an intracerebral clip, as well as claustrophobic subjects, neurosensory stimulator or implantable defibrillator, cochlear implants, body Foreign ferromagnetic ocular or cerebral close to nerve structures, agitation of the subject (non-cooperating or agitated subjects), ventriculoperitoneal neurosurgical bypass valves, dental apparatus.

• Persons under guardianship, curatorship or any other administrative or judicial measure of deprivation of rights or liberty, as well as persons of legal age protected by law.

• Participants refusing to be informed of the results of the medical examination (inclusion).

• Participants refusing to be informed of the possible detection of an anomaly.

Related Conditions & MeSH terms

• Healthy

Intervention

Other:
• fMRI study
Functional brain activations of face-voice processing during a gender task

Locations

Country	Name	City	State
France	Le VINATIER	Bron

Sponsors (1)

Lead Sponsor	Collaborator
Hospices Civils de Lyon

Country where clinical trial is conducted

France, 

References & Publications (6)

Charrier C, Knoblauch K, Maloney LT, Bovik AC, Moorthy AK. Optimizing multiscale SSIM for compression via MLDS. IEEE Trans Image Process. 2012 Dec;21(12):4682-94. doi: 10.1109/TIP.2012.2210723. Epub 2012 Jul 30. — View Citation

Gerardin P, Devinck F, Dojat M, Knoblauch K. Contributions of contour frequency, amplitude, and luminance to the watercolor effect estimated by conjoint measurement. J Vis. 2014 Apr 10;14(4). pii: 9. doi: 10.1167/14.4.9. — View Citation

Gerardin P, Kourtzi Z, Mamassian P. Prior knowledge of illumination for 3D perception in the human brain. Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16309-14. doi: 10.1073/pnas.1006285107. Epub 2010 Aug 30. — View Citation

Markov NT, Ercsey-Ravasz M, Van Essen DC, Knoblauch K, Toroczkai Z, Kennedy H. Cortical high-density counterstream architectures. Science. 2013 Nov 1;342(6158):1238406. doi: 10.1126/science.1238406. Review. — View Citation

Pegado F, Comerlato E, Ventura F, Jobert A, Nakamura K, Buiatti M, Ventura P, Dehaene-Lambertz G, Kolinsky R, Morais J, Braga LW, Cohen L, Dehaene S. Timing the impact of literacy on visual processing. Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):E5233-42. doi: 10.1073/pnas.1417347111. Epub 2014 Nov 24. — View Citation

Wacongne C, Changeux JP, Dehaene S. A neuronal model of predictive coding accounting for the mismatch negativity. J Neurosci. 2012 Mar 14;32(11):3665-78. doi: 10.1523/JNEUROSCI.5003-11.2012. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Identify neural correlates (fMRI) of face / voice interaction in a gender classification task	Classical functional analyses (GLM) and advanced statistical analyses of brain activations (BrainVoyager and Matlab softwares).	Maximum 90 days between inclusion of the subject and the 1st fMRI session (1h1 / 2). Then maximum 90 days before the 2nd session (1h1 / 2).
Primary	Identify neural correlates (fMRI) of face / voice respective contribution in a gender classification task	Classical functional analyses (GLM) and advanced statistical analyses of brain activations	Maximum 90 days between inclusion of the subject and the 1st fMRI session (1h1 / 2). Then maximum 90 days before the 2nd session (1h1 / 2).