Healthy Clinical Trial
Official title:
Reactivity of the Vestibular System to Caloric Vestibular Stimulation in Schizophrenia
Verified date | February 2024 |
Source | Centre for Addiction and Mental Health |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This study aims to determine if individuals with schizophrenia have greater reactivity to vestibular stimulation than healthy controls. The physiological response of vestibular stimulation will be assessed with electronystagmography, which provides a measure of the intensity of the nystagmus via PSPV. Positive results would suggest greater vestibular system reactivity to vestibular stimulation may be a biomarker of schizophrenia. Pathophysiologically, increased vestibular reactivity to vestibular stimulation may reflect abnormal vestibular function or impaired central suppression of the vestibular ocular reflex.
Status | Completed |
Enrollment | 40 |
Est. completion date | December 31, 2023 |
Est. primary completion date | December 31, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria for Schizophrenia group: 1. Male or female inpatients or outpatients age =18 2. Having a DSM-5 diagnosis of schizophrenia or schizoaffective disorder 3. Voluntary and capable of consenting to participation in the research study 4. Fluent in English Inclusion Criteria for Healthy Controls group: 1. Male or female and age =18 2. Voluntary and capable of consenting to participation in the research study 3. Fluent in English 4. Absence of history of psychiatric illness using the Mini-International Neuropsychiatric Interview (MINI) Exclusion Criteria for all participants: 1. Serious unstable medical illness or any concomitant major medical or neurological illness 2. Acute suicidal and/or homicidal ideation 3. Formal thought disorder rating of over 2 on the Scale for Assessment of Positive Symptoms (SAPS) [patients only] 4. DSM-IV substance dependence (except caffeine and nicotine) within one month prior to entering the study 5. Pregnant women 6. Positive urine drug screen 7. History of external or middle ear pathology 8. History or signs of middle ear surgery (e.g. Tympanoplasty, mastoidectomy) 9. Signs of active ear disease |
Country | Name | City | State |
---|---|---|---|
Canada | Centre for Addiction and Mental Health | Toronto | Ontario |
Lead Sponsor | Collaborator |
---|---|
Centre for Addiction and Mental Health |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Nystagmus response (peak slow phase velocity) | Nystagmus response will be measured at between thirty and 60 seconds post irrigations, looking for the highest velocities. | Between 30 and 60 sec after each CVS condition | |
Secondary | Illness awareness | Changes in illness awareness will be assessed using a questionnaire. | Before CVS session and10 min after CVS session |
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