Healthy Clinical Trial
Official title:
Dose-response Effect of Alcohol Ingestion on Steroid Profile: Gender and Ethnic Aspects
The aim of the clinical trial is to study the intra-individual variation of steroid profile parameters after experimental administration of different doses of ethanol in Caucasian women.
The introduction of the so called 'endocrine module' of the athlete's biological passport
needs to consider the numerous reports showing the effect of ethanol ingestion on the steroid
profile. A steroid profile would only be useful for longitudinal monitoring and statistical
evaluation if it has not been altered by any uncontrolled circumstance, very particularly
alcohol consumption.
There is an urgent need to study the perpetuation that alcohol ingestion causes to the
individual steroid profile and if possible establish cut-off values for markers of ethanol
ingestion granting that the steroid profile determined has not been affected by such
ingestion.
Subjects will be genotyped for genetic deletion polymorphism in the uridine
diphosphoglucuronosyltransferase family 2 member B17 gene (UGT2B17) related to testosterone
glucuronidation regulation.
The objective of the clinical trial is to study the intra-individual variation of steroid
profile parameters as a result of the ingestion of different doses of ethanol in Caucasian
women (complementing previous studies performed in men).
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