Protein Requirements for Active Adolescent Females

Healthy Clinical Trial

— IAAO-AF  

Official title:

Evaluation of Protein Requirements in Active Adolescent Females

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02800239
• Other study ID #: IAAO-AF
• Status: Completed
• Phase: N/A
• Start date: February 2016
• Est. completion date: December 31, 2017

Study information

• Verified date: March 2019
• Source: University of Toronto
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Protein requirements in active individuals have been suggested to be greater than the current recommended dietary allowance (RDA).

Nutritional requirements for dietary amino acids in adolescents have traditionally been determined utilizing the nitrogen balance technique, which is prone to underestimating protein requirements. As a result, there is a need to re-evaluate recommendations in order to characterize how dietary amino acid needs may be modulated by physical activity.

Recent studies using the minimally invasive indicator amino acid oxidation (IAAO) technique have suggested that protein requirements in young men are at least 50% higher than the RDA based on nitrogen balance data.

The purpose of this study is to measure the protein requirement in adolescent, females using the IAAO technique in the presence of a variable intensity exercise stimulus.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 7
• Est. completion date: December 31, 2017
• Est. primary completion date: October 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 10 Years to 15 Years

Eligibility

Inclusion Criteria (Adolescents):

• Healthy, active adolescent who regularly participates in moderate to vigorous physical activity 5 times a week for a minimum of 1 hour.

• Being -0.5 to +1.0 years from peak height velocity, determined by the ratio of standing to sitting height, with the maximal age for adolescents being 16 years.

Obtaining a minimum level of 5.8 on the Beep Test

Exclusion Criteria (All Subjects):

• Inability to meet health and physical activity guidelines according to the Physical Activity Readiness Questionnaire (PAR-Q+) and Physical Activity Questionnaire,

• An inability to adhere to any of the protocol guidelines (i.e. caffeine consumption)

• A biological age falling outside of the aforementioned ranges

Related Conditions & MeSH terms

• Healthy
• Increased Metabolic Requirement

Intervention

Dietary Supplement:
• Amino Acid Intake
Amino acid intakes will be varied at 0.2-2.67 g/kg/d

Locations

Country	Name	City	State
Canada	Goldring Centre for High Performance Sport	Toronto	Ontario

Sponsors (2)

Lead Sponsor	Collaborator
University of Toronto	Ajinomoto Co., Inc.

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	13CO2 ([13]Carbon Dioxide) Excretion (µmol/kg/h)		4 hours/ study day
Secondary	[13C]Phenylalanine Oxidation (µmol/kg/h)		4 hours/ study day