Healthy Clinical Trial
Official title:
The Effect of Acute Lysine Administration on α-aminoadipic Acid
Verified date | February 2017 |
Source | Vanderbilt University Medical Center |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This study aims to assess the effect and breakdown of lysine administration, specifically examining whether it leads to increased plasma 2-AAA in healthy humans.
Status | Completed |
Enrollment | 13 |
Est. completion date | October 1, 2016 |
Est. primary completion date | October 1, 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 45 Years |
Eligibility |
Inclusion Criteria: - BMI 18 to <25 kg/m2 - Men and women ages 18-45 years Exclusion Criteria: - Current use of prescription medications (apart from hormonal birth control) - Current use of amino acid supplements (including branched-chain amino acids) or supplemental protein (habitual consumption of protein powder, bars, shakes), and unwilling to temporarily discontinue use (1 week prior to study visit) - Individuals who currently use tobacco products or have done so in the previous 30 days - Prior or current cardiovascular disease, renal disease, or liver disease - Diabetes mellitus (taking insulin, other anti-diabetic agents, or diet-controlled) - Atrial fibrillation - Bleeding disorder or anemia - Positive pregnancy test - Women who are breastfeeding - Participation in another clinical trial within the previous 6 weeks prior to the study visit - Inability to provide written informed consent - Inability to fast for 8 hours |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Vanderbilt University |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in plasma 2-AAA from baseline to peak post-lysine ingestion (anticipated 2-4 hours post-ingestion) | The primary goal is to detect whether there is a measurable increase in 2-AAA in plasma following lysine administration. Samples will be measured at baseline (pre-ingestion) and serially post-ingestion. Relative concentrations are determined through mass spectrometry, and expressed in arbitrary units. | Baseline and 2-4 hours | |
Secondary | Change in urinary 2-AAA from baseline to peak post-lysine ingestion (anticipated 2-4 hours post-ingestion) | A secondary goal is to detect whether there is a measurable increase in 2-AAA in urine following lysine ingestion. Relative concentrations are determined through mass spectrometry, and expressed in arbitrary units. | Baseline and 2-4 hours |
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