Healthy Clinical Trial
Official title:
Scalp Hair Estradiol and Progesterone Level Determination in Pre-menopausal and Post-menopausal Women (Proof of Concept Study)
The investigators hypothesis is that we can determine estrogen and progesterone levels in the hair by using the immune method and we can show a significant difference in the levels of these hormones in both groups of women: pre- and postmenopausal women. If indeed it would then be possible in future to carry out research that can find a relationship between the levels of these hormones and various diseases
One group will include 20 women under the age 40 years old, with regular menstruation cycles
and without any illness or medication including birth control pills or steroidal ointments,
and without known diagnosis of polycystic ovaries or fertility disorder. The second group
will include 20 women over the age of 60, with no menstruation at least for the last five
years, and without hormone therapy or treatment of any Steroidal therapy for the last year.
From all of the participants the investigators will collect hair samples at the crown back
of the head (hair will be cut as close as possible to the scalp), the samples will be
measured quantitatively about 100 hairs at a length of 2-3 cm. In order to grind the hair
samples we will use a mini-Bead beater machine. milled hairs will be incubated overnight in
a solution of 1 ml methanol 50, in constant gentle muddling. Afterwards, ethanol will
disperse through a stream of nitrogen. The remainder of the suspension will be dissolved at
200 microliter buffer PBS (Phosphate-Buffered Saline) (pH 8.0) and the concentration of
estrogen and progesterone will be measured by using the immune method which is available in
the endocrine laboratory in Bnai Zion medical center. At the end of the study the
investigators will cary out a statistical comparison of progesterone and estrogen levels
between the two groups.
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Observational Model: Cohort, Time Perspective: Cross-Sectional
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