Magnetic Resonance Imaging of Human Supraclavicular Brown Adipose Tissue - MIBAT Study

Healthy Clinical Trial

— MIBAT  

Official title:

Magnetic Resonance Imaging of Human Supraclavicular Brown Adipose Tissue - MIBAT Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02682706
• Other study ID #: EKNZ BASEC 2015-00199
• Status: Completed
• First received: February 10, 2016
• Last updated: April 5, 2018
• Start date: February 2016
• Est. completion date: March 2018

Study information

• Verified date: April 2018
• Source: University Hospital, Basel, Switzerland
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Brown adipose tissue (BAT) is unique in its capability to convert chemical energy directly into heat. Active BAT increases energy expenditure and can thereby counteract obesity and insulin resistance. Currently, the imaging method of choice to assess BAT morphology and function is 18F-FDG-PET/CT which is expensive and exposes patients or healthy volunteers to ionizing radiation, thus impeding larger prospective studies.

Magnetic resonance imaging (MRI) could constitute a suitable alternative and preliminary small-scale studies are promising.

The overall aim of this research proposal is to develop reliable magnetic resonance imaging techniques to facilitate the study of brown adipose tissue in human adults, specifically in the context of endocrine disease.

Specifically, investigators want to

1. Develop a reliable MR imaging protocol for human BAT and compare BAT volume to cold induced nonshivering thermogenesis as a measure of BAT activity.

2. Assess the intra-individual variance of BAT volume measured by MRI.

3. Evaluate direct measurement of BAT temperature by functional MRI.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 26
• Est. completion date: March 2018
• Est. primary completion date: March 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• Healthy volunteers

• Age 18-40 years

• Body mass index (BMI): 17.5-27 kg/m²

Exclusion Criteria:

• known concomitant disease influencing thyroid hormone metabolism

• severe diseases: chronic heart failure, liver cirrhosis, kidney failure, active cancer

• known hypersensitivity to cold, e.g. primary or secondary Raynaud's syndrome

• abuse of alcohol or illicit drugs

• Women who are pregnant or breast feeding

• Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant

• Previous enrolment into the current study

• implanted device not compatible with MRI, e.g. pace maker

Related Conditions & MeSH terms

• Healthy

Locations

Country	Name	City	State
Switzerland	University Hospital Basel, Department of Endocrinology	Basel	BS
Switzerland	University Hospital of Basel, Department of Radiology	Basel	BS

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Basel, Switzerland

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Correlation of scBAT volume and cold induced thermogenesis as determined by indirect calorimetry	measurement of scBAT volume and measurement of cold induced thermogenesis as determined by indirect calorimetry, both values measured in a timeframe of two weeks	both measurements within 2 weeks