Healthy Clinical Trial
Official title:
Assessment of the Changes in Cortical and Medullary Renal Blood Flow During Exercise in Healthy Subjects Using Contrast Enhanced Ultrasound
Renal parenchymal blood flow can be divided in cortical and medullary blood flow. Changes and factors affecting renal medullary blood flow have not been studied in detail previously as investigators/doctors did not have tools to monitor renal medullary blood flow in vivo. Since Trueta first described renal medullary blood flow, multiple attempts have been made to study renal medullary blood flow using invasive methods. Recently renal medullary blood flow measurement using contrast US has emerged as a promising technique that investigators can use to study renal medullary blood flow in vivo. In this study investigators are aiming to study changes in renal parenchymal (cortical and medullary) blood flow with exercise in healthy subject.
Status | Recruiting |
Enrollment | 19 |
Est. completion date | October 2017 |
Est. primary completion date | August 2017 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 50 Years |
Eligibility |
Inclusion Criteria: - Healthy Adult - 18 to 50 years old - All ethnicity and genders Exclusion Criteria: - Pregnancy or lactation - Active infection - Hypertension - Chronic Medication Use except Multi Vitamin Use and Birth Control Medications - Known history of a right to left intra-cardiac shunt - Known history of pulmonary hypertension, including porto-pulmonary hypertension - History of allergies to Definity® - History of Liver or Kidney Transplant - Patient on hemodialysis - Has received iodinated contrast within 72 hours of admission to study |
Country | Name | City | State |
---|---|---|---|
United States | University of Virginia | Charlottesville | Virginia |
Lead Sponsor | Collaborator |
---|---|
University of Virginia |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in renal blood flow in exercise as assessed by CEUS | Total, cortical and medullary kidney blood flow will be measured using contrast-enhanced ultrasonography | Before and immediately after exercise |
Status | Clinical Trial | Phase | |
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