Healthy Clinical Trial
— EAOfficial title:
Application of Indicator Amino Acid Oxidation Method to Investigate the Rate-limiting Amino Acids in Endurance Trained Athlete
NCT number | NCT02628249 |
Other study ID # | IAAO-EA |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | September 2015 |
Est. completion date | December 2017 |
Verified date | March 2019 |
Source | University of Toronto |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Protein requirements in individuals who participate in endurance-based exercise training have
been suggested to be greater than the current recommended dietary allowance (RDA).
The biological value of protein depends on the amino acid composition. As liebig's law of the
minimum, the protein synthesis is limited due to the lack of single rate limiting amino acid.
In this case, the first rate limiting amino acid determines protein intakes to maximize the
protein synthesis. Adding a small amount of rate-limiting amino acid to the diet improves the
biological value of its protein diet.
The indicator amino acid oxidation (IAAO) method has clarified the individual amino acid
requirement in children, normal healthy adult and clinical populations. however, the IAAO
method has never been utilized for determining the first rate limiting amino acid.
Therefore, the purpose of this study is to address of IAAO method to be applied for
determining the rate-limiting amino acid in endurance athlete.
Status | Completed |
Enrollment | 5 |
Est. completion date | December 2017 |
Est. primary completion date | June 2017 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 35 Years |
Eligibility |
Gender: Male Age limit: Minimum age 18 years - Maximum age 35 years Accepts Healthy Volunteers : yes Inclusion Criteria: - Endurance-trained participants who regularly more than 40 km/week - Ability to perform the exercise stimulus (20 km run) on metabolic trial. Exclusion Criteria: - Inability to meet health and physical activity guidelines according to the physical activity readiness questionnaire (PAR-Q+) - Inability to adhere to any of the protocol guidelines (i.e. alcohol, caffeine consumption) - Regular tobacco use - Illicit drug use |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
University of Toronto |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | 13CO2 (carbon dioxide) excretion rate (µmol/kg/h) | 8 hours after exercise followed by ingesting 13C-labelled phenylalanine and one of 5 different amount of amino acids intake, 13CO2 excretion rate is determined by multiplying the enrichment of 13CO2 in breath measured by Mass spectrometry and CO2 production rate measured by metabolic cart. | At 8 hours after the end of exercise | |
Secondary | [13C]phenylalanine oxidation rate (µmol/kg/h) | 8 hours after exercise followed by ingesting 13C-labelled phenylalanine and one of 5 different amount of amino acids intake, 13CO2 excretion rate is determined dividing 13CO2 excretion rate by urinary enrichment of 13C-phenylalanine in breath measured by Mass spectrometry, and CO2 production rate measured by metabolic cart. | at 8 hours after the end of exercise |
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