Healthy Clinical Trial
Official title:
Impact of Training Status of Endurance Athletes on Bioavailability of Flavanones
Flavonoids are compounds that have been proven to have a beneficial effect on health, such
as reducing the risk of developing cardiovascular disease and, in some cases, cancer. Citrus
juices have a high flavonoid content. However, the absorption of flavonoids into the body is
limited. This study will investigate whether being physically active improves the absorption
of flavonoids.
Endurance trained athletes will be invited to participate. Following screening procedures
(a. Health Screening Questionnaire; b. height and weight measurement for calculation of Body
Mass Index; c. maximal oxygen consumption (VO2max) uptake test, eligible participants will
undertake two experimental tests; one during a period of normal training, the other
immediately following 1 week of detraining.
In the morning of the experimental trial participants will consume 500 mL of orange juice.
Blood samples and urinary fractions will be collected prior (base line) to and for 24 hours
after orange juice consumption. Participants will be asked to follow a special
polyphenol-free diet and record weighed dietary intake for 2 days preceding each trial and
during the day of the experimental trial.
The study aims to:
1. Determine the effects of training status of endurance athletes on bioavailability of
flavanones in endurance trained individuals
2. Determine whether changes in bioavailability of flavanones are related to changes in
biomarkers of inflammation, oxidative stress, plasma lipids and insulin sensitivity.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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