Strength Training Adaptations, Age and Genes

Healthy Clinical Trial

— STAGE  

Official title:

Effect of Maximal Strength Training in Relation to Age and Genes

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02589990
• Other study ID #: STAGE
• Status: Completed
• Phase: N/A
• Start date: January 2016
• Est. completion date: September 3, 2018

Study information

• Verified date: September 2018
• Source: Telemark University College
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The study investigates the effect of maximal strength training on muscular strength and power in different age groups from 20 to 80 year old. It also relates the training adaptations to different known genes such as angiotensin I-converting enzyme (ACE) and Alpha-actinin-3 (ACTN3). Participants will complete an eight weeks, three times per week training intervention of maximal strength training with a pre-post design. In addition, blood samples will be collected for the analyses of genetic variances.

Description:

Aim: The study aims to investigate the effect of age and genes on training adaptations to a maximal strength training intervention.

Methods: Participants will be recruited through invitations at work places and other community arenas. The investigators aim to recruit 10-15 subjects in each of the following age groups: 20-29, 30-39, 40-49, 50-59, 60-69 and 70-80 years of age. Both genders will be included. All age groups will be matched for age-related baseline maximal strength and distribution between the two genders. All participants will be checked via a health registration scheme, and excluded if contra indications for hard physical training or testing should appear. When in doubt, the projects physician will decide on inclusion or exclusion due to a thorough examination. Subjects will give a blood sample to be analyzed for known genes such as ACE and ACTN3. The intervention has a pre- post design. Tests of maximal strength and power will be conducted in a leg-press machine, using the protocol assessing one repetition maximum (1RM) previously described. Force and Power will be measured by the Muscle Lab system from Ergotest Tech. (Langesund, Norway). The intervention is an eight week, three times per week protocol, each training session consisting of a standardized warm-up, and 4 repetitions x 4 sets with an intensity of 4 repetition maximum (4RM) performed in the leg press machine.There will be a three minutes pause between sets. Participants will be given instructions and supervision.

Hypothesis: Maximal strength training adaptations will be affected by age and baseline maximal strength but not by gender or genetic variations.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 76
• Est. completion date: September 3, 2018
• Est. primary completion date: August 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 90 Years

Eligibility

Inclusion Criteria:

• Healthy adults 20 to 90 years old

Exclusion Criteria:

• Contraindications to maximum strength training and testing

Related Conditions & MeSH terms

• Healthy

Intervention

Behavioral:
• Strength training
see arm description

Locations

Country	Name	City	State
Norway	Telemark University College	Bø	Telemark
Norway	Norwegian University of Science and Technology	Trondheim

Sponsors (2)

Lead Sponsor	Collaborator
Telemark University College	Norwegian University of Science and Technology

Country where clinical trial is conducted

Norway, 

References & Publications (2)

Støren O, Helgerud J, Støa EM, Hoff J. Maximal strength training improves running economy in distance runners. Med Sci Sports Exerc. 2008 Jun;40(6):1087-92. doi: 10.1249/MSS.0b013e318168da2f. — View Citation

Sunde A, Støren O, Bjerkaas M, Larsen MH, Hoff J, Helgerud J. Maximal strength training improves cycling economy in competitive cyclists. J Strength Cond Res. 2010 Aug;24(8):2157-65. doi: 10.1519/JSC.0b013e3181aeb16a. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Maximal muscle strength measured by 1 RM leg press in leg press machine		8 weeks
Secondary	Blood sample will be collected to assess gene types Alpha Actinin 3, Angiotensin Converting Enzyme, Angiotensinogen		8 weeks
Secondary	rate of force development in leg press measured by MuscleLab (Ergotest Tech., Langesund Norway)		8 weeks
Secondary	agility will be measured by counter movement jump using the MuscleLab system by Ergotest Tech. (Langesund, Norway)		8 weeks