Protein Requirements in Endurance-trained Athlete

Healthy Clinical Trial

— EP  

Official title:

Evaluation of Protein Requirements in Male Endurance Athletes

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02478801
• Other study ID #: IAAO-E
• Status: Completed
• Phase: Phase 0
• First received: June 18, 2015
• Last updated: June 15, 2016
• Start date: March 2015
• Est. completion date: May 2016

Study information

• Verified date: June 2016
• Source: University of Toronto
• Contact: n/a
• Is FDA regulated: No
• Health authority: Canada: Ethics Review Committee
• Study type: Interventional

Clinical Trial Summary

Protein requirements in individuals who participate in endurance-based exercise training have been suggested to be greater than the current recommended dietary allowance (RDA).

Nutritional requirements for dietary amino acids in adults have traditionally been determined utilizing the nitrogen balance technique, which is prone to underestimating protein requirements. As a result, there is a need to re-evaluate recommendations in order to characterize how dietary amino acid needs may be modulated by physical activity.

Recent studies using the minimally invasive indicator amino acid oxidation (IAAO) technique have suggested that protein requirements in young men are at least 50% higher than RDA based on nitrogen balance data.

Therefore, the purpose of this study is to measure the protein requirement in endurance trained adults using the IAAO technique.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 9
• Est. completion date: May 2016
• Est. primary completion date: January 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• Healthy, male, endurance-trained participants who regularly more than 40 km/week

• Ability to perform the exercise stimulus (20 km run) on metabolic trial.

Exclusion Criteria:

• Inability to meet health and physical activity guidelines according to the physical activity readiness questionnaire (PAR-Q+)

• Inability to adhere to any of the protocol guidelines (i.e. alcohol, caffeine consumption)

• Regular tobacco use

• Illicit drug use

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Healthy
• Increased Metabolic Requirement

Intervention

Dietary Supplement:
• amino acids intake
amino acids intakes will be varied at 0.2-2.8 g/kg/day

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
University of Toronto	Ajinomoto Co., Inc.

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	13CO2 (carbon dioxide) excretion (µmol/kg/h)		4 hours / study day	No
Secondary	[13C]phenylalanine oxidation (µmol/kg/h)		4 hours/study day	No