Vestibular Pain Interactions

Healthy Clinical Trial

— VPI  

Official title:

Modulation of Pain Responses by Vestibular Stimulation. A Contact Heat Evoked Potential Study.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02358954
• Other study ID #: VPI01
• Status: Completed
• Phase: N/A
• First received: January 22, 2015
• Last updated: July 11, 2015
• Start date: January 2015
• Est. completion date: June 2015

Study information

• Verified date: July 2015
• Source: University of Zurich
• Contact: n/a
• Is FDA regulated: No
• Health authority: Switzerland: Ethikkommission
• Study type: Interventional

Clinical Trial Summary

The goal is to establish the practical usefulness of vestibular stimulation for modulating pain perception and to describe the possible mechanisms that could underlie neural vestibular-somatosensory interactions.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 26
• Est. completion date: June 2015
• Est. primary completion date: June 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• Weight: 50 - 100 kg

• Height: 155 - 185 cm

• Male subjects 18 years to 60 years of age

• Sufficient command of German language

• Written informed consent by the participant after information about the project

• Without any known history of neurological disease (especially motor, somatosensory disorders, peripheral neuropathies).

• Right-handedness

Exclusion Criteria:

1. Intellectually or mental impaired subjects

2. Drug abuse

3. Chronic alcohol consumption

4. No use of marihuana 24h before measurements.

5. No history of vestibular or auditory disorders.

6. Diabetes mellitus

7. Participants of other studies during study period and 30 days prior to study begin

8. Any regular concomitant medication

9. Abnormal QST parameters at the baseline measurement.

10. Absent CHEPs-Potentials at the baseline measurement.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Related Conditions & MeSH terms

• Healthy

Intervention

Procedure:
• Quantitative sensory testing
Measurement of warm and cold detection and pain thresholds
• CHEPS
Measurement of amplitude and latency of cortically evoked potentials
• 3D Turntable

• Vection stimulation

Locations

Country	Name	City	State
Switzerland	University hospital Zurich	Zurich

Sponsors (1)

Lead Sponsor	Collaborator
University of Zurich

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Pain thresholds	The change in heat or cold pain threshold after physical vestibular stimulation and vection stimulation	After study inclusion, Day1	No