Healthy Clinical Trial
Official title:
Intramuscular and Functional Effects and Mechanism of Partitioning the Exercising Muscle Mass in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Recent work have shown that low load, high-repetitive single limb resistance training, if
compared to a control, can increase limb muscle function and functional exercise capacity in
patients with chronic obstructive pulmonary disease (COPD) while avoiding the occurrence of
limiting exertional symptoms. However, no comparison to another exercise regimen have been
performed. In addition neither the intramuscular nor the mechanism of this exercise regimen
have been investigated and represents the aim of the proposed project. We will in a
prospective, assessor-blind; block randomized controlled, parallel-group trial compare
single-limb to two-limb low load, high-repetitive resistance training in patients with severe
and very severe COPD
The research hypothesizes are:
- that single-limb low-load high-repetitive resistance training will provide larger gain
in the 6-min walking distance than two-limb low-load high- repetitive resistance
training in patients with severe to very severe (stage III-IV) COPD.
- that eight weeks of single limb training should also be associated with larger
physiological (increased muscle endurance, less muscle fatigue and deoxygenation) and
structural (muscle protein synthesis, fiber-type distribution and capillarization)
muscle adaptations to training, lower cardio- respiratory demand, as well a greater
increase in health-related quality of life in comparison to two-limbs simultaneous
training.
We will also compare the groups at baseline to investigate the acute effects and mechanisms
of single-limb to two-limb low load, high-repetitive resistance training, a comparison that
also will include healthy matched controls.
The research hypothesizes are:
- that involving a large muscle mass during exercise (e.g., two-limb low load,
high-repetition resistance training) compared to involving a small muscle mass during
training (e.g., single limb low load, high-repetition resistance training) would lead to
larger restraints on the cardiorespiratory system in patients with severe to very severe
COPD. Conversely, single limb interventions should produce less dyspnea and more muscle
deoxygenation and fatigue than two-limb simultaneous exercise while healthy controls
will be able to perform both legs/arms exercise without a central constraint, and no
negative consequences on muscle fatigue or exercise stimulus.
n/a
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