Healthy Clinical Trial
Official title:
Gut Microbial Response to Well-balanced Diet With Emphasis on Animal or Vegan Protein
Gut microbiota are involved in the regulation of mammalian metabolic pathways through
host-microbiota metabolic, signaling, and immune-inflammatory interactions that
physiologically connect the gut, liver, brain, and other organs. Correlation of these
metabotypes with gut microbial profiles facilitates deciphering inherent host-microbe
relationships.
Microbiome sequencing have generated novel insights into the role of gut microbial
composition in health and disease, but are limited in addressing the microbial contribution
to host metabolism and the gut microbial dysbiosis in disease.
This is an exploratory trial, aiming to examine how gut microbial conditions determine
response to dietary challenge by measuring urine, plasma and stool metabolites resulting
from metabolism of protein, polyamines and bile acids in combination with stool bacterial
composition. The focus of this trial is to evaluate impact of protein based food challenges,
based on cross-over design of two diet challenges of animal and vegan protein sources.
n/a
Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science
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