Healthy Clinical Trial
Official title:
Coffee and Glucose Metabolism: Clinical, Crossover and Randomized Glucose Disposal Assay Using Stable Isotopes
Epidemiological studies have shown an inverse association between coffee consumption and
risk of type 2 diabetes mellitus (T2DM). However the experimental studies that analysed the
mechanisms are limited.
This project aims to assess the effects of coffee consumption on glucose metabolism, using
stable isotope tracer (13C-glucose) to explain the possible metabolic mechanisms involved on
the reduced risk for T2DM.
This is a crossover randomized clinical trial that has been studying 14 male healthy young
adults, who were enrolled five treatments: coffee with sugar, coffee without sugar,
decaffeinated coffee without sugar and two controls (water with and without sugar).
The stable isotope minimal model protocol with oral glucose administration (Oral Dose
Intravenous Label Experiment - ODILE) was performed. The use of ODILE methodology permits
separation of the glucose absorbed and removed from the circulation increasing the accuracy
and the effectiveness of glucose uptake and insulin sensitivity (Bluck et al., 2006).
;
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Investigator), Primary Purpose: Basic Science
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