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NCT02053701 Clinical Trial

High-field Brain Magnetic Resonance Spectroscopy

Healthy Clinical Trial

Official title:
Technical Developments for High-field Brain Magnetic Resonance Spectroscopy

Clinical Trial Details — Status: Active, not recruiting

Administrative data
NCT number NCT02053701
Other study ID # 1210M23141
Secondary ID P41EB015894
Status Active, not recruiting
Phase
First received
Last updated
Start date June 1, 2010
Est. completion date November 2030

Study information
Verified date March 2024
Source University of Minnesota
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Magnetic resonance spectroscopy (MRS) allows non-invasive measurement of the concentration of up to 18 metabolites in the brain ("neurochemical profile"). The objective of this proposal is to develop new methods for high-field brain MRS (3 to 7 Tesla). Our main hypothesis is that higher magnetic fields lead to improved spatial and temporal resolution and improved quantification precision. Aims 1. To obtain improved "neurochemical profiles" in the brain using single voxel proton MRS at very high field (3 Tesla to 7 Tesla). 2. To develop new methods for proton magnetic resonance spectroscopic imaging (MRSI) to obtain metabolic maps at very high field (3 Tesla to 7 Tesla). Since this project is focused on technical development, only healthy volunteers will be recruited (no patients).

Recruitment information / eligibility
Status Active, not recruiting
Enrollment 30
Est. completion date November 2030
Est. primary completion date November 2030
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - over 18 years old Exclusion Criteria: - no metallic implant or other MRI-incompatible device

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
United States Center for Magnetic Resonance Research Minneapolis Minnesota

Sponsors (2)
Lead Sponsor Collaborator
University of Minnesota National Institute for Biomedical Imaging and Bioengineering (NIBIB)

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Precision of quantification of brain metabolites concentrations This protocol is devoted exclusively to technical development and testing of MRS methods on our MR scanners. As such, there is no well-defined outcome measure or time frame. It is a continuous effort. We recruit subjects on an ongoing basis to test, optimize, and assess the performance of newly developed techniques. One time only
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