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The Effects of Prazosin on Dopamine in Healthy Humans: A PET Pilot Study

Healthy Clinical Trial

Official title:
Exploring the Effects of Prazosin on Basal Dopamine in Healthy Humans: A [11C]-(+)-PHNO PET Pilot Study

Clinical Trial Summary

The purpose of this study is to find out whether short term treatment with a antihypertensive medication prazosin, can influence the levels of a dopamine in the brain. We will examine the levels of dopamine in the the brain using Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI). We hypothesize that there will be no significant changes in dopamine levels in healthy individuals taking prazosin.

Clinical Trial Description

The purpose of this study is to find out whether short term treatment with a antihypertensive medication prazosin, can influence the levels of dopamine in the brain. We will examine the levels of dopamine in the the brain using Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI). The study will involve three PET scans and one MRI. One PET scan will be performed before the participants take prazosin for approximately three weeks, and the last two PET scans will be performed after the prazosin medication phase. We hypothesize that there will be no significant changes in dopamine levels in healthy individuals taking prazosin. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01999530
Study type Interventional
Source Centre for Addiction and Mental Health
Contact
Status Completed
Phase Phase 1
Start date November 2013
Completion date August 2016
View Details
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