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Molecular and Functional PET-fMRI Measures of Analgesia in Migraine

Healthy Clinical Trial

Official title:
Molecular and Functional PET-fMRI Measures of Analgesia in Migraine

Clinical Trial Summary

The placebo effect is a phenomenon that has experienced major advances of its understanding in the last decade. However, mechanisms of placebo analgesia in chronic pain patients have yet to be compared to healthy subjects. The investigators study aims to investigate the magnitude of placebo response and related opioid release in patients that suffer from episodic migraines as compared to healthy controls. In particular, the investigators are looking to map brain activity during placebo analgesia using modern brain imaging techniques such as functional Magnetic Resonance Imaging (fMRI) and Positron Emission Tomography (PET). The investigators hypothesis is that placebo response and the availability of opioid receptors is reduced in chronic migraine patients.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01970943
Study type Interventional
Source Massachusetts General Hospital
Contact
Status Completed
Phase N/A
Start date September 1, 2012
Completion date October 30, 2017
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