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NCT01772784 Clinical Trial

Effects of Phenolic Acids on Endothelial Function

Healthy Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01772784
Other study ID # 11.36.NRC
Secondary ID
Status Completed
Phase N/A
First received July 25, 2012
Last updated January 17, 2013
Start date June 2012
Est. completion date November 2012

Study information
Verified date November 2012
Source Nestlé
Contact n/a
Is FDA regulated No
Health authority Switzerland: Swissmedic
Study type Interventional

Clinical Trial Summary

Epidemiological studies suggest dietary (poly) phenols decrease the risk of death from cardiovascular diseases. (Poly)phenol-rich foods include fruits and vegetables as well as tea, coffee, red wine, and chocolate. The aim of the present study is to investigate whether endothelial function is altered by ingestion of phenolic acids. Moreover, the investigators will evaluate the effect of phenolic acids on blood pressure and platelet adhesion.

Recruitment information / eligibility
Status Completed
Enrollment 24
Est. completion date November 2012
Est. primary completion date November 2012
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Male
Age group 18 Years to 75 Years
Eligibility Inclusion Criteria:

- Healthy

- males

- Smokers

Exclusion Criteria:

Any food allergy

- Abnormal blood pressure defined as follow: systolic <100 or >160 mmHg and diastolic <50 or >100mmHg

- Regular consumption of medication within 2 months before the study inclusion

- Caffeine intake 1 day before screening measurements (and 1 day before each visit),

- Any intake of multivitamin-tablets and other supplemental compounds 10 days before the study start and throughout the study.

- Excessive alcohol intake defined as > 280 g per week

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator)

Related Conditions & MeSH terms

Intervention

Other:
• Phenolic acids
Phenolic acids

Locations
Country Name City State
Switzerland Swiss Cardiovascular Center Bern, University Hospital Bern

Sponsors (1)
Lead Sponsor Collaborator
Nestlé

Country where clinical trial is conducted

Switzerland, 

Outcome
Type Measure Description Time frame Safety issue
Primary endothelial dysfunction 1 hour No
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