Healthy Clinical Trial
Official title:
Effect of Topical Glaucoma Therapy on Tear Film Stability in Healthy Subjects
Long term treatment with anti-glaucomatous drugs has been shown to increase the incidence of
dry eye syndrome with all known consequences such as ocular discomfort and epithelial
keratitis. Given that thinning of the tear film appears to be a risk factor for the
development or the aggravation of dry eye syndrome, the current study seeks to investigate
whether tear film thickness is changed after topical treatment with anti-glaucomatous drugs
in healthy subjects.
For this purpose, tear film thickness will be measured at baseline and after single
instillation of one of 5 study drugs in one randomly chosen eye. In addition, one group of
20 subjects will receive no drug and will serve as a second control. Drug effects on tear
film thickness will be compared to the fellow, non-treated eye. In addition, effects on tear
film thickness of timolol with preservatives (Timoptic 0.5%) will be compared to timolol
without preservatives (Timophtal sine 0.5%) and three lubricants with different viscosity
(Genteal HA, Hylo-Comod, Thealoz).
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Basic Science
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