Healthy Clinical Trial
Official title:
Investigation Into Incorporation of (n-3) Polyunsaturated Fatty Acids Into Erythrocyte Membranes and Clearance, and Effects on Platelet Function, Arterial Function and Endothelial Repair
The purpose of this study was to determine whether supplementation with oils enriched with long chain n-3 PUFA, either EPA or DHA, had a differential effect on platelet, endothelial and vascular function.
Relatively few studies have made a head-to-head comparison of DHA (22:6n-3) with EPA
(20:5n-3). The understanding of this differential effect may be of great interest in
populations with low EPA intake such as vegetarians, who may choose to supplement their
dietary intake of long-chain n-3 PUFA in the form of DHA-rich algal oil.
This study aimed to investigate the effect of supplementation with oils rich in either EPA or
DHA (3g/day, 6 weeks) in healthy young males on platelet, endothelial and vascular function,
as well as other CVD risk factors. The primary outcomes were platelet monocyte aggregates and
endothelial progenitor cells - novel markers of platelet and endothelial function, measured
by flow cytometry, Secondary outcomes included capillary density, measured by capillaroscopy
to assess changes in microvascular function, pulse wave analysis, digital volume pulse and
ambulatory blood pressure. Other secondary outcomes included lipid profiles (TAG,
cholesterol, NEFA), glycaemic control (HOMA, QUICKI) and oxidative stress (isoprostane). The
omega-3 index (erythrocyte EPA+DHA) was used as a marker of compliance.
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