Healthy Clinical Trial
Official title:
The Effect of Capsaicin and Cinnamaldehyde on Intestinal Permeability, Gallbladder Motility and Satiety
An altered permeability has been proposed to play an important role in the pathogenesis of
several gastrointestinal disorders, such as irritable bowel syndrome and inflammatory bowel
disease. Nutrients derived from food are able to influence the permeability of the intestine
and can therefore also affect gastrointestinal symptoms. In this study, the investigators
will investigate the effects of capsaicine and cinnamaldehyde, which can be found in hot
peppers and cinnamon, respectively, on gastrointestinal physiology.
Objective:
To obtain more information about the effects of capsaicin and cinnamaldehyde on the
intestine, these substances will be infused directly in the duodenum. Hereafter, the
permeability of the intestine, gallbladder motility and the effects on satiety will be
assessed.
Hypothesis:
Duodenal capsaicin and cinnamaldehyde infusion induces changes in the intestinal epithelial
barrier function by selectively acting on TRPV1 and TRPA1 receptors and releasing serotonin
from enterochromaffin cells as determined by the multi sugar permeability test
n/a
Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science
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