Study of Electroencephalogram (EEG) Measurement During Different Stimulations of the Lower Urinary Tract

Healthy Clinical Trial

Official title:

Investigation of Lower Urinary Tract Afferent and Cortical Brain Activity During Lower Urinary Tract Stimulation Using Electroencephalogram Measurements

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01389921
• Other study ID #: 25/2009
• Status: Completed
• Phase: N/A
• Start date: February 2011
• Est. completion date: April 2014

Study information

• Verified date: July 2019
• Source: University of Zurich
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to investigate afferent and cortical activities during bladder filling under different stimulations of the lower urinary tract. The participants of the study are healthy test persons and patients with overactive bladder.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 83
• Est. completion date: April 2014
• Est. primary completion date: September 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Right-handed

• Written informed consent

Exclusion Criteria:

• Any psychological diseases

• Any renal, cardiac, and pulmonary diseases

• Pregnancy or breastfeeding

• Problems keeping calm for 60 minutes in the sitting position

• Medication influencing EEG or bladder function

Related Conditions & MeSH terms

• Healthy
• Neurogenic Bladder Dysfunction Nos
• Nonneurogenic Neurogenic Bladder Dysfunction
• Urinary Bladder, Neurogenic

Intervention

Other:
• Electroencephalography
Standard electroencephalography investigation according to the ICS standard Current recording of latency and amplitude of evoked potentials

Locations

Country	Name	City	State
Switzerland	Spinal Cord Injury & Research, University of Zürich, Balgrist University Hospital	Zürich

Sponsors (2)

Lead Sponsor	Collaborator
Ulrich Mehnert	NCCR (National Center of Competence in Resaerch, Switzerland)

Country where clinical trial is conducted

Switzerland, 

References & Publications (3)

Gregorini F, Knüpfer SC, Liechti MD, Schubert M, Curt A, Kessler TM, Mehnert U. Sensory evoked potentials of the bladder and urethra in middle-aged women: the effect of age. BJU Int. 2015 Apr;115 Suppl 6:18-25. doi: 10.1111/bju.13066. — View Citation

Gregorini F, Wöllner J, Schubert M, Curt A, Kessler TM, Mehnert U. Sensory evoked potentials of the human lower urinary tract. J Urol. 2013 Jun;189(6):2179-85. doi: 10.1016/j.juro.2012.11.151. Epub 2012 Nov 30. — View Citation

Knüpfer SC, Liechti MD, Gregorini F, De Wachter S, Kessler TM, Mehnert U. Sensory function assessment of the human male lower urinary tract using current perception thresholds. Neurourol Urodyn. 2017 Feb;36(2):469-473. doi: 10.1002/nau.22956. Epub 2016 Jan 15. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Establishment of somatosensory evoked potentials of lower urinary tract stimulations	EEG recording during electrical stimulation of different locations of the lower urinary tract as well as during electrical and heat stimulation at the tibial and pudendal nerve and S3 dermatome.	3 times on an average period of three months