Branched-chain Amino Acids, and Resistance Exercise on Skeletal Muscle Signaling Pathways

Healthy Clinical Trial

Official title:

Effects of Leucine, Branched-chain Amino Acids, and Resistance Exercise on Skeletal Muscle Remodelling Signaling Pathways: a Randomized, Double-blind, and Placebo-controlled Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01350427
• Other study ID #: 2011/04690-6
• Status: Completed
• Phase: N/A
• First received: May 2, 2011
• Last updated: February 22, 2013
• Start date: August 2011
• Est. completion date: February 2013

Study information

• Verified date: February 2013
• Source: University of Sao Paulo
• Contact: n/a
• Is FDA regulated: No
• Health authority: Brazil: Ethics Committee
• Study type: Interventional

Clinical Trial Summary

This study aims to evaluate the effects of leucine and branched-chain amino acids supplementation on skeletal muscle remodeling signaling pathways induced by resistance exercise.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 18
• Est. completion date: February 2013
• Est. primary completion date: February 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• Sedentaries

• Must be able to exercise

• Must be able to swallow tablets

Exclusion Criteria:

• Use of nutritional supplements

• Use of anti-inflammatory drugs

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Healthy

Intervention

Dietary Supplement:
• Leucine supplementation
1 bout of resistance exercise and supplementation of 4.0 g of leucine + 5.6 g of alanine
• BCAA supplementation
1 bout of resistance exercise and supplementation of 4.0 g of leucine + 2.8 g of isoleucine + 2.8 g of valine
• Alanine supplementation
1 bout of resistance exercise and supplementation of 9.6 g of alanine

Locations

Country	Name	City	State
Brazil	University of São Paulo - School of Physical Education and Sports	São Paulo

Sponsors (1)

Lead Sponsor	Collaborator
University of Sao Paulo

Country where clinical trial is conducted

Brazil, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Protein synthesis	Phosphorylation of proteins involved in protein synthesis	1 hour	Yes
Primary	Protein degradation	Expression of protein involved in proteolytic pathway	1 hour	Yes
Primary	Inflammation	Expression of systemic and muscular cytokines	1 hour	Yes