Healthy Clinical Trial
Official title:
Technique Optimization and Anatomy of the Human Body With Whole-body Diffusion-weighted MRI: Study With Healthy Volunteers
Whole body diffusion-weighted imaging is a functional magnetic resonance imaging technique
that characterizes tissue by probing changes in water diffusion secondary to differences in
the tissue microstructure. These changes in water diffusion result in differences in signal
intensity on diffusion-weighted images that are quantified with the apparent diffusion
coefficient (ADC). In malignant lesions, the extravascular extracellular space (EES) will be
diminished, due to the increased number of cells. This will restrict water diffusion,
identified by increased signal intensity (SI) on native diffusion-weighted images and low
ADC. Contrary, in tissue with low cellularity, like benign lesions and treatment induced
necrosis, the EES will be enlarged due to the lower density of cells, or in case of
necrosis, the complete absence of cellular organization. This will facilitate water
diffusion, leading to absent SI on native diffusion-weighted images and high ADC.
The purpose of this study is to image anatomy and lymph nodes in healthy volunteers with
whole body diffusion-weighted imaging. This way maps of normal anatomy can be created on the
whole body diffusion-weighted images which can be used as a reference in further studies
with patients scanned with the same whole body diffusion-weighted imaging scan protocol.
A group of 30 healthy volunteers will receive a whole body diffusion-weighted imaging scan
on a 3 Tesla T-MRI system.
A total scan session will take about 30 minutes. Contrast administration is not required and
patients will not be exposed to radiation.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label
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