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A Phase 1 Absolute Bioavailability Study For Oral Crizotinib In Healthy Volunteers

Healthy Clinical Trial

Official title:
A Phase 1, Single Dose, Randomized, Cross-Over Absolute Bioavailability Study In Healthy Volunteers Comparing Oral To Intravenous Administration Of Crizotinib (PF-02341066)

Clinical Trial Summary

This study will be an open-label, randomized, 2-period, 2-treatment, 2-sequence, cross-over single-dose study to test the absolute bioavailability of oral crizotinib formulation to IV formulation in healthy adult volunteers. Fourteen (14) subjects will be enrolled to obtain at least 12 evaluable subjects who complete the study. Each subject will receive two treatments (A and B) with a washout period of at least 14 days between each treatment.

Clinical Trial Description

evaluate the absolute bioavailability of oral crizotinib to IV crizotinib. ;

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Parallel Assignment, Masking: Open Label

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01168934
Study type Interventional
Source Pfizer
Contact
Status Completed
Phase Phase 1
Start date August 2010
Completion date September 2010
View Details
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