Healthy Clinical Trial
Official title:
Comparison of Plasma Volume Determination by 99mTc-labeled Albumin and 125I-labeled Albumin
The purpose of the present study is to compare plasma volume determination by 99mTc-labeled albumin with 125I-labeled albumin. Fifteen subjects will be enrolled. The hypothesis is that plasma volume determined by the different methods are the same.
For many years, radioiodinated albumin has been "the golden standard" for measurement of
plasma volume. There are a number of clinical situations in which a nuclide with a shorter
half-life would be preferred. Furthermore, due to periodic lapses in the availability in the
delivery of 125I-labeled albumin, there is a need to evaluate another nuclide as a tracer
for plasma volume determination.
99mTc-labeled albumin is easily prepared by a simple and reproducible method with a high
labeling efficiency and short half-life.
In this study, we want to compare plasma volume determined by 99mTc-labeled albumin with
plasma volume determined by 125I-albumin (golden standard). In both procedures, plasma
volume is estimated from multiple postinjection samples for accurate zero-time extrapolation
in order to correct for leakage of labeled albumin from the vascular compartment.
;
Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Basic Science
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