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NCT00978640 Clinical Trial

Sirtuin Mediated Effects of 36 Hour Fast and 1 Hour Exercise

Healthy Clinical Trial

Official title:
Sirtuin Mediated Effects of 36 h Fast and 1 h Exercise

Clinical Trial Details — Status: Active, not recruiting

Administrative data
NCT number NCT00978640
Other study ID # 07.09.2009
Secondary ID
Status Active, not recruiting
Phase N/A
First received September 16, 2009
Last updated June 19, 2012
Start date September 2009
Est. completion date June 2012

Study information
Verified date June 2012
Source University of Aarhus
Contact n/a
Is FDA regulated No
Health authority Denmark: Ethics Committee
Study type Interventional

Clinical Trial Summary

Hypothesis: during fasting and exercise will there be an activation of sirtuins (Sirt1).

Primarily the investigators will investigate Sirt1 activity in muscle- and fat-biopsies after fasting for 36 hours and after 1 hour of ergometer-cycling at 50 Vo2max.

In addition to this the investigators will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.

Recruitment information / eligibility
Status Active, not recruiting
Enrollment 8
Est. completion date June 2012
Est. primary completion date June 2012
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Male
Age group 18 Years to 45 Years
Eligibility Inclusion Criteria:

- healthy men

- Body mass index (BMI) 20-26

- age 18-45 years

Exclusion Criteria:

- any kind of disease

- any use of medicine

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

Intervention

Other:
• fast and exercise
fasting 36 h and exercise 1 h 50% VO2max
• exercise
exercise 1 h 50% VO2max

Locations
Country Name City State
Denmark mikkel Holm Vendelbo Århus Jylland

Sponsors (1)
Lead Sponsor Collaborator
University of Aarhus

Country where clinical trial is conducted

Denmark, 

Outcome
Type Measure Description Time frame Safety issue
Primary Sirt1 activity 60 min No
Secondary secondary will we investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover. 4 h No
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