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Effects of Ethanol on Intestinal Permeability and Integrity

Healthy Clinical Trial

Official title:
The Effect of Ethanol on Intestinal Permeability and Integrity in Healthy Individuals

Clinical Trial Summary

Alcohol consumption is a major health problem worldwide. It affects all systems of the body especially the gastrointestinal tract. Acute or chronic alcohol consumption has deleterious effects on the gastrointestinal mucosa vary from increased intestinal permeability, structural changes to sever destruction of the epithelial lining cells. Human data are still limited and most of the studies were performed in chronic alcohol abusers.

The investigators hypothesize that moderate alcohol drinking also may increase small intestinal permeability and contribute to the subsequent disruption of the tight junction complex. This study may provide more insight into the effects of moderate alcohol drinking on the small intestinal permeability.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Investigator)

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00928733
Study type Interventional
Source Maastricht University Medical Center
Contact
Status Completed
Phase N/A
Start date September 2009
Completion date January 2012
View Details
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