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Evaluation of a Nasal Allergen Challenge Procedure Using Dust Mite Extract — Dusty  

Healthy Clinical Trial

Official title:
Evaluation of the Safety and Effect of an Allergen Challenge Procedure on Nasal Airway Inflammation in Allergic Individuals Using a Dermatophagoides Farinae Extract Nasal Allergen Challenge Protocol

Clinical Trial Summary

The purpose of this study is to serve as a pilot safety study for nasal allergen challenges.

Clinical Trial Description

The purpose of this study is to serve as a pilot safety study for the implementation of a new technique for nasal allergen challenges. The new technique consists of having patients maximally inhale to total lung capacity. A nasal metered dose pump will be used to deliver the Dermatophagoides farinae allergen to the nasal mucosa. The patient will not sniff after allergen delivery as in the previous study but instead exhale through the mouth. The investigators propose that this technique will inhibit large amounts of allergen reaching airway mucosa beyond the nasal site of introduction thus limiting serious adverse events. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00927329
Study type Interventional
Source University of North Carolina, Chapel Hill
Contact
Status Withdrawn
Phase Phase 1
Start date January 2009
Completion date April 2017
View Details
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