Healthy Clinical Trial
Official title:
Role of Endothelin-1 in Optic Nerve Head Blood Flow Regulation During Isometric Exercise in Healthy Humans
Autoregulation is defined as the ability of a vascular bed to adapt its vascular resistance
to changes in perfusion pressure. In the eye, several studies have reported that retinal
blood flow is autoregulated over a wide range of ocular perfusion pressures. The
investigators could recently show that Endothelin-1 is a key metabolite in the regulation of
vascular tone in the eye and plays an important role in the blood flow autoregulation of the
choroidal circulation. However, no data is yet available for the optic nerve head. Thus, the
present study is designed to test the hypothesis that Endothelin-1 plays also a role in
optic nerve head blood flow autoregulation.
Therefore, subjects will perform squatting to increase systemic perfusion pressure during
administration of either an endothelin A-receptor blocker (BQ-123) or placebo. Optic nerve
head blood flow will be continuously measured during the procedure to investigate optic
nerve head autoregulation.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science
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