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NCT00817440 Clinical Trial

Effects of Fasting and Exercise on Insulin and GH Signaltransduction in Muscle and Fat

Healthy Clinical Trial

— FEIGH  

Official title:
Effects of Fasting and Exercise on Insulin and GH Signaltransduction in Muscle and Fat

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00817440
Other study ID # 16.12.2008
Secondary ID
Status Completed
Phase N/A
First received January 5, 2009
Last updated January 10, 2011
Start date December 2008

Study information
Verified date January 2011
Source University of Aarhus
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Hypothesis: under fasting there will primarily be an activation of growth hormone(GH) signalpathways and a inhibition of insulin signalpathways, and the opposite will happen under physical activity.

Primarily we will investigate markers for GH and insulin signaltransduction in muscle- and fat-biopsies after fasting for 72 hours and after 1 hour of ergometer-cycling at 65% Vo2max.

In addition to this we will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.

Recruitment information / eligibility
Status Completed
Enrollment 8
Est. completion date
Est. primary completion date May 2009
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Male
Age group 18 Years to 45 Years
Eligibility Inclusion Criteria:

- healthy men

- Body mass index (BMI) 20-26

- age 18-45 years

Exclusion Criteria:

- any kind of disease

- any use of medicine

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Exercise
1 hour ergometer cycling on 65% of Vo2max, and then the same as arm 1.
• Fasting
3 days of fasting and then the same as arm 1

Locations
Country Name City State
Denmark Aarhus sygehus Aarhus Jylland

Sponsors (1)
Lead Sponsor Collaborator
University of Aarhus

Country where clinical trial is conducted

Denmark, 

Outcome
Type Measure Description Time frame Safety issue
Primary Growth hormone and insulin signal pathways 30 min
Secondary aminoacid and glucose turnover 4 hours
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