Force Enhancement of Musculus Quadriceps Femoris During and After Excentric Muscle Activity in Vivo

Healthy Clinical Trial

Official title:

Force Enhancement of m. Quadriceps Femoris During and After Excentric Muscle Activity in Vivo by Maximal and Sub-maximal Deliberately Activation.

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT00690547
• Other study ID #: DFG27112007
• Status: Active, not recruiting
• Phase: N/A
• First received: May 30, 2008
• Last updated: November 27, 2009
• Start date: October 2008
• Est. completion date: October 2010

Study information

• Verified date: November 2009
• Source: German Research Foundation
• Contact: n/a
• Is FDA regulated: No
• Health authority: Germany: German Research Foundation (DFG)
• Study type: Observational

Clinical Trial Summary

Force enhancement (FE) describes the phenomenon of strength potentialization of a muscle cell or the complete muscle during and after active extension compared to the strength of an isometric contraction with same muscle length. The underlying physiological mechanism of this phenomenon is not completely known today. In vitro trials indicate that the interaction of an active and a passive component on the cellular level are responsible for the higher strength measurements. So far FE could be shown in vitro and in vivo on muscle fibers and small human muscles. Further research is needed for verification of the existence of FE in voluntary motor activity in everyday life. In order to approach this objective the investigators will scrutinize the functionality of the deliberately activated musculus (m) quadriceps femoris during and after active extension on the basis of in vivo studies.

Description:

The research proposal is resubmitted with no amendments made regarding content.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 60
• Est. completion date: October 2010
• Est. primary completion date: October 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 20 Years to 40 Years

Eligibility

Inclusion Criteria:

• Males without previous muscular or neurophysiological diseases

• Age between 20 and 40 years

Exclusion Criteria:

• Previous muscular or neurophysiological diseases

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

• Healthy
• Muscle Quadriceps Femoris

Intervention

Other:
• muscle activation
activation of the muscle quadriceps femoris

Locations

Country	Name	City	State
Germany	Technical University of Munich, Department of Biomechanics in Sports	Munich

Sponsors (1)

Lead Sponsor	Collaborator
German Research Foundation

Country where clinical trial is conducted

Germany, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Identification of a potential Force enhancement by complex muscle activity with a high relevance for everyday life, for example more agile leg stretching (knee bend).		12 months	No
Secondary	Evidence of existence of the force enhancement by deliberately activated, great human muscle by sub-maximal activation		12 months	No
Secondary	Correlation between typ of muscle fiber and force enhancement in vivo		12 months	No
Secondary	Analysis of the alternation of length of the muscle fiber during and after excentric extension for the differentiated explanation of in vivo mechanism excentric and post-excentric strength		12 months	No