Healthy Clinical Trial
Official title:
CGRP-induced Headache in Patients With Familial Hemiplegic Migraine, Migraine With Aura and Healthy Controls
The aim of the present study is to explore the importance of migraine phenotype on the headache/migraine responses after CGRP in FHM-patients, MA-patients and healthy volunteers.
Calcitonin gene-related peptide (CGRP) induces migraine attacks indistinguishable from
spontaneous attacks in a large proportion of migraine sufferers. Treatment of spontaneous
migraine attacks with an inhibitor of CGRP is effective in many patients. These data show
that CGRP is involved in migraine pathophysiology.
The importance of migraine genetics is disputed. Evidence from FHM patients with known
mutations indicates that migraine pathways in FHM may be different from normal migraine. The
aim of the present study is to examine whether this difference also exists in FHM patients
without known mutations. The project will improve our understanding of the neurobiology of
migraine and stimulate development of new treatment targets.
;
Allocation: Non-Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
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