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NCT00660465 Clinical Trial

Exploring the Relationship Between Varying CO2 Levels and the Regional BOLD Signal, by Using Breathing Exercises

Healthy Clinical Trial

Official title:
Exploring the Relationship Between Varying CO2 Levels and the Regional BOLD Signal, by Using Breathing Exercises .

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT00660465
Other study ID # SOR467608CTIL
Secondary ID
Status Not yet recruiting
Phase N/A
First received April 15, 2008
Last updated November 9, 2014
Start date May 2008

Study information
Verified date February 2008
Source Soroka University Medical Center
Contact Alexander Gersten, Ph.D
Phone +972-52-3906012
Email alex.gersten@gmail.com
Is FDA regulated No
Health authority Israel: Ministry of Health
Study type Observational

Clinical Trial Summary

The purpose of this study is to explore how arterial PaCO2 effect regional Blood Oxygen Level Dependent (BOLD) signal, and indirectly the brain regional O2 level .

Description:

Among many parameters effecting cerebral blood flow(CBF), partial pressure of CO2 (PaCO2) in arterial blood has a significant effect. A small increase in arterial PaCO2 level will cause a significant increase of CBF , followed by increase of O2 level . The main objective is to explore the effect of arterial PaCO2 level on regional CBF and brain O2 level, by using breathing exercises to modulate arterial PaCO2. The regional Blood Oxygen Level Dependent (BOLD) signal produced by MRI , will indicate the regional O2 level.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 6
Est. completion date
Est. primary completion date
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 18 Years to 75 Years
Eligibility Inclusion Criteria:

- adults over 18 years old .

Exclusion Criteria:

- under 18 years old.

- Artificial pacemaker

- implantable cardioverter-defibrillator (ICD)

- Hearing aid, implantable or portable.

- artificial heart valve

- Surgical clips

- Metal fragments in eyes

- Electronic stimulators

- Implanted pumps

- Implantable Neurostimulation Device

- metal fragments of any sort

- Permanent makeup or tattoo

- transfusion pump

- pregnant or breast feeding women

- False teeth , retainer or dental crown

Study Design

Observational Model: Case-Only, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Locations
Country Name City State
Israel Department of Diagnostic Imaging ;Soroka Univrsity Medical Center Beer Sheva

Sponsors (1)
Lead Sponsor Collaborator
Soroka University Medical Center

Country where clinical trial is conducted

Israel, 

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