The Effect of Aging and Immobilisation on Muscle

Healthy Clinical Trial

Official title:

The Effect of Aging and Immobilisation on Muscle

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00559806
• Other study ID #: KF01-322606
• Status: Completed
• Phase: N/A
• First received: November 15, 2007
• Last updated: November 15, 2007
• Start date: January 2007
• Est. completion date: May 2007

Study information

• Verified date: November 2007
• Source: Bispebjerg Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Denmark: National Board of Health
• Study type: Interventional

Clinical Trial Summary

The debilitating effects of immobilisation on muscle strength and size in young individuals are well documented. Moreover, sarcopenia has long been recognized as a major cause of muscle strength loss in old age, however, changes in muscle mass and architecture with immobilisation in the elderly has not previously been investigated. This is contrasted by the fact that the elderly population more often undergoes periods of immobilization and disuse not only due to joint pain but also due to a higher degree of co morbidity and hospitalisation.The purpose of the present study was to compare the effect of a 2 week period of unilateral immobilisation on the physiological muscle cross sectional area, maximal isometric muscle strength, specific force, muscle fascicle length and muscle fibre pennation angle in young and old healthy men.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: May 2007
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 20 Years to 80 Years

Eligibility

Inclusion Criteria:

• Young healthy males (age 20-30 yrs)or old healthy males (age 60-80 yrs)

Exclusion Criteria:

• Musculoskeletal disorder

• Diabetes

• Cardiovascular disease

• Neurological diseases; or

• Cognitive disorders

Study Design

Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Healthy

Intervention

Other:
• 2 weeks of unilateral immobilisation and 4 weeks of resistance training
2 weeks of whole leg casting (side randomized)followed by 4 weeks of unilateral resistance training. The non-imm side served as a within-subject control
• 2 weeks of unilateral immobilisation and 4 weeks of resistance training
2 weeks of unilateral whole leg casting (side randomized)followed by 4 weeks of unilateral resistance training. The non-imm side served as a within-subject control

Locations

Country	Name	City	State
Denmark	Institute of Sports Medicine, Bispebjerg Hospital	Copenhagen

Sponsors (1)

Lead Sponsor	Collaborator
Bispebjerg Hospital

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	muscle cross sectional area, maximal isometric muscle strength, specific force, muscle fascicle length and muscle fibre pennation		2 weeks of immobilisation and 4 weeks of resistance training
Secondary	single muscle fiber area, expression of myostatin and IGF-1 (RNA), changes in satellite activation and number		2 weeks of imm and 4 weeks of resistance training