Healthy Clinical Trial
Official title:
Mechanistic Study (Physiology)
Context: Cholecystokinin (CCK) and neurotensin are stimulated during meal intake by the
presence of fat in the small intestine. The sequence of events suggests that fat hydrolysis
is crucial for triggering the release.
Objectives: The aim of this study was therefore to investigate whether CCK mediated the
effect of intraduodenal (ID) fat on neurotensin secretion via CCK-1 receptors.
Setting: Single center study; 34 male volunteers were studied in consecutive, randomized,
double blind, crossover studies.
Subjects and Methods: CCK and neurotensin release were quantified in: 1) 12 subjects
receiving an ID fat infusion with or without 60 mg orlistat, an irreversible inhibitor of
gastrointestinal lipases, in comparison to vehicle. 2) 12 subjects receiving ID long chain
fatty acids (LCF), ID medium chain fatty acids (MCF) or ID vehicle. 3) 10 subjects receiving
ID LCF with and without the CCK-1 receptor antagonist dexloxiglumide (DEXLOX) or ID vehicle
plus IV saline (placebo). Hormone concentrations were measured by specific RIA systems.
;
Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science
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