Healthy Clinical Trial
Official title:
Effect of Neutralization of Endogenous Acid Production on Bone Mineral Density and Microarchitectural Composition of Bone in Humans
Hypothesis: Neutralization of acid production induced by the Western diet with oral administration of potassium citrate increases bone mineral density and bone mass as well as skeletal muscle mass and strength in elderly people (> 65y).
We will perform a prospective, randomized, placebo-controlled trial evaluating the effect of
K citrate on bone mineral density, microarchitectural composition of bone,nutritional
parameters, lean body mass, parameters of skeletal muscle mass and strength, 24h and
exercise induced blood pressure changes in otherwise healthy, elderly ambulatory subjects of
both genders.
Potassium citrate (60 mEq) is supplied as tablets with a wax matrix (10 mEq of citrate per
tablet) and ingested in three doses/day. All subjects will receive daily oral 500 mg of
calcium and 400 IU of vitamin D to ensure adequate calcium and vitamin D supply.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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