Interruption of Dorsal Visual Stream Using TMS

Healthy Clinical Trial

Official title:

Interruption of Dorsal Visual Stream Using TMS in Normal Controls

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00418652
• Other study ID #: SHEBA-06-4252-RA-CTIL
• Status: Completed
• Phase: N/A
• First received: January 4, 2007
• Last updated: August 3, 2011
• Start date: January 2006

Study information

• Verified date: August 2011
• Source: Sheba Medical Center
• Contact: n/a
• Is FDA regulated: No
• Health authority: Israel: Israeli Health Ministry Pharmaceutical Administration
• Study type: Interventional

Clinical Trial Summary

Trans Cranial Magnetic Stimulation (TMS) over dorsal visual system will disturb the ability to identify objects with decreased level of fragmentation

Description:

The participants performed two tasks under three different TMS conditions: no TMS, 10Hz TMS for over the dorsal stream (PO3 EEG site) or over the vertex.

First they performed a perceptual closure task which asked them to identify an object in a series of six progressively less degraded pictures.

Then, they also performed a control task previously shown not to be mediated by the LOC and not to be impaired in schizophrenia: The perception of illusory contours.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. primary completion date: July 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Normal controls

Exclusion Criteria:

• neurological, ophthalmological or psychiatric problems

• family history of schizophrenia

• left handed

Study Design

Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Single Blind (Subject), Primary Purpose: Diagnostic

Related Conditions & MeSH terms

• Healthy

Intervention

Device:
• No TMS intervention
In the "no TMS" condition, no simulation was given and no coil placed near participants' heads.
• TMS over the PO3 EEG site
10Hz TMS over the dorsal stream (PO3 EEG site)
• TMS over the vertex
10Hz TMS for over vertex.

Locations

Country	Name	City	State
Israel	Psychiatry Clinic - Sheba Medical Center	Tel-hashomer

Sponsors (1)

Lead Sponsor	Collaborator
Sheba Medical Center

Country where clinical trial is conducted

Israel, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Results of the study assignments performed by the participants during the study.	The subjects performed 2 tasks: The primary dependent measures consisted of the level of detail needed for correct object identification, response accuracy, and response time in milliseconds for correct responses.; Illusory Contour Task: Subjects also performed a pulsed pedestal task, Participants were shown 55 drawings for 500 ms each. Some drawings contained partial contours which defined a geometric shape, while in others the contours did not define a shape. Participants were asked to indicate whether they recognized a geometric shape or not. Accuracy and response time were measured.	The participants performed the tasks once during their study visit	No