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NCT00281762 Clinical Trial

Urinary Aquaporin 2 Excretion After NSAID in Fasting Healthy Human

Healthy Clinical Trial

Official title:
Urinary Aquaporin 2 Excretion After NSAID in Fasting Healthy Human

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00281762
Other study ID # MED.RES.HOS.2005.01.TGK
Secondary ID
Status Completed
Phase Phase 4
First received January 23, 2006
Last updated May 6, 2008
Est. completion date January 2007

Study information
Verified date May 2008
Source Regional Hospital Holstebro
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

We wanted to test the hypothesis that prostaglandin inhibition reduces the down regulation of u-AQP-2 induced by fasting

Recruitment information / eligibility
Status Completed
Enrollment 20
Est. completion date January 2007
Est. primary completion date January 2007
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 65 Years
Eligibility Inclusion Criteria:

- (1) Genders; both mal and female

- (2) Age; 18- 65 years old

- (3) BMI; below 30

- (4) Females had to bee in oral contraceptive treatment

Exclusion Criteria:

- (1) Clinical signs or history of disease in the heart, lungs, kidneys or endocrine organs

- (2) Abnormal laboratory test (blood haemoglobin, white cell count, platelets, plasma sodium, plasma potassium, plasma creatinine, plasma albumin, plasma bilirubin, plasma alanine aminotransferase, plasma cholesterol and blood glucose)

- (3) Albuminuria or glucosuria

- (4) Cancer

- (5) Arterial hypertension

- (6) Alcohol abuse

- (7) Use of tobacco

- (8) Medical treatment, except oral contraceptives

- (9) Pregnancy or breast feeding

- (10) Medicine abuse

- (11) Donation of blood less than 1 month before the study.

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• NSAID

Locations
Country Name City State
Denmark Department of Medicine, Holstebro Hospital Holstebro

Sponsors (1)
Lead Sponsor Collaborator
Regional Hospital Holstebro

Country where clinical trial is conducted

Denmark, 

Outcome
Type Measure Description Time frame Safety issue
Primary FeNa
Primary U-AQP-2
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