Healthy Clinical Trial
Official title:
Effect of Volitional Inhibition on Cortical Inhibitory Mechanisms
This study will use transcranial magnetic stimulation to examine how the brain controls
movement by sending messages to the spinal cord and muscles and what goes wrong with this
process in disease. Normal healthy volunteers between the ages of 18 and 65 years may be
eligible to participate.
In transcranial magnetic stimulation, an insulated wire coil is placed on the subject's
scalp or skin. Brief electrical currents are passed through the coil, creating magnetic
pulses that stimulate the brain. During the stimulation, participants will be asked to tense
certain muscles slightly or perform other simple actions. The electrical activity of the
muscle will be recorded on a computer through electrodes applied to the skin over the
muscle. In most cases, the study will last less than 3 hours.
Status | Completed |
Enrollment | 30 |
Est. completion date | June 2002 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | N/A and older |
Eligibility |
Volunteers who are greater than or equal to 18 years old. Subjects must not have any medico-surgical illness. Subjects must not have neurological illness. Subjects must not have psychiatric illness. Subjects must not be taking any medication with potential influence on nervous system function. Subjects must not have a pacemaker. Subjects must not have an implanted medical pump. Subjects must not have a metal plate or a metal object in the skull or eye. Subjects must not have a history of seizure disorder. |
N/A
Country | Name | City | State |
---|---|---|---|
United States | National Institute of Neurological Disorders and Stroke (NINDS) | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Institute of Neurological Disorders and Stroke (NINDS) |
United States,
Colebatch JG, Rothwell JC, Day BL, Thompson PD, Marsden CD. Cortical outflow to proximal arm muscles in man. Brain. 1990 Dec;113 ( Pt 6):1843-56. — View Citation
Fuhr P, Agostino R, Hallett M. Spinal motor neuron excitability during the silent period after cortical stimulation. Electroencephalogr Clin Neurophysiol. 1991 Aug;81(4):257-62. — View Citation
Triggs WJ, Cros D, Macdonell RA, Chiappa KH, Fang J, Day BJ. Cortical and spinal motor excitability during the transcranial magnetic stimulation silent period in humans. Brain Res. 1993 Nov 19;628(1-2):39-48. — View Citation
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