Healthy Clinical Trial
Official title:
Adolescence, Puberty, Hormones, and Emotion Regulation: An fMRI Study
Verified date | October 18, 2017 |
Source | National Institutes of Health Clinical Center (CC) |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The purpose of this study is to use brain imaging technology to compare how the brains of
adolescents and adults are activated during tasks that involve emotional responses.
Evidence suggests that adolescents and adults experience activation in similar brain regions
when they engage in tasks that involve the processing of emotional stimuli. However, the
degree of task-associated activation may differ between adolescents and adults. This study
will use functional magnetic resonance imaging (fMRI) to compare brain activation patterns in
adolescents and adults. This study will also be used to develop emotion-evoking fMRI tasks to
determine whether there are puberty and age-linked components of brain development.
Status | Completed |
Enrollment | 300 |
Est. completion date | October 18, 2017 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | All |
Age group | 8 Years to 55 Years |
Eligibility |
- INCLUSION CRITERIA: HEALTHY SUBJECTS: Age: 9-25 (adolescents/young adults); 25-35 (adults). Consent: can give consent/assent. Parents will provide consent for all minors. IQ: all subjects will have an IQ greater than 70; assessment relies on WASI. Psychopathology: all subjects will be free of any current psychiatric disorder as well as lifetime history of psychosis, pervasive developmental disorder, major affective disorder, panic disorder, obsessive compulsive disorder, conduct disorder, ADHD, and anorexia. Assessment relies on comprehensive psychiatric interview. INCLUSION CRITERIA: ENDOCRINE AND CARRIER PATIENTS Age: 9-25 (adolescents/young adults); 25-35 (adults). Consent: can give consent/assent. Parents will provide consent for all minors. IQ: all subjects will have an IQ greater than 70. Assessment relies on WASI EXCLUSION CRITERIA: Any medical condition that increases risk for MRI (e.g. pacemaker, metallic foreign body in eye) Pregnancy |
Country | Name | City | State |
---|---|---|---|
United States | National Institutes of Health Clinical Center, 9000 Rockville Pike | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Institute of Mental Health (NIMH) |
United States,
Kessler RC, McGonagle KA, Zhao S, Nelson CB, Hughes M, Eshleman S, Wittchen HU, Kendler KS. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry. 1994 Jan;51(1):8-19. — View Citation
Pine DS, Cohen P, Gurley D, Brook J, Ma Y. The risk for early-adulthood anxiety and depressive disorders in adolescents with anxiety and depressive disorders. Arch Gen Psychiatry. 1998 Jan;55(1):56-64. — View Citation
Weissman MM, Bland RC, Canino GJ, Faravelli C, Greenwald S, Hwu HG, Joyce PR, Karam EG, Lee CK, Lellouch J, Lépine JP, Newman SC, Oakley-Browne MA, Rubio-Stipec M, Wells JE, Wickramaratne PJ, Wittchen HU, Yeh EK. The cross-national epidemiology of panic disorder. Arch Gen Psychiatry. 1997 Apr;54(4):305-9. — View Citation
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