Healthy Clinical Trial
Official title:
Genetic Studies of Tune Deafness
Verified date | June 29, 2010 |
Source | National Institutes of Health Clinical Center (CC) |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
This study will examine the hereditary basis of tone deafness by identifying regions of the
human genome linked to this condition. Both exceptionally good pitch recognition (perfect
pitch) and exceptionally poor pitch recognition (tone deafness) run in families. A better
understanding of what causes tone deafness may provide new insights into auditory (hearing)
function.
Individuals with two or more family members 15 years of age or older who are tone deaf or
have trouble recognizing different melodies may be eligible for this study. Candidates will
be screened with a short listening test for pitch and a short written test. Those identified
with poor pitch recognition will fill out a brief questionnaire about their family tree and
family members (without identifying names) who have trouble recognizing melodies or tones.
Individuals with poor pitch recognition will be asked to help contact family members who may
be interested in participating.
Members of families with two or more first-degree relatives (parents, grandparents, siblings)
who are tone deaf may enroll in the study. They will provide a blood sample (about 2
tablespoons) for genetic studies and may take a 20-minute hearing test using headphones.
Status | Completed |
Enrollment | 968 |
Est. completion date | June 29, 2010 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | All |
Age group | 15 Years and older |
Eligibility |
- INCLUSION CRITERIA: Individuals over the age of 15. This study includes both males and females, and includes members of all racial and ethnic groups. This study includes both normal and tune deaf individuals, as well as individuals that may have intermediate scores on the Distorted Tunes Test, indicating a status between completely tune deaf and normal. EXCLUSION CRITERIA: Hearing impaired individuals, as first estimated by a score of 25 or greater on the American Academy of Otolaryngology's 5 Minute Hearing Test, or subsequently by audiological exam. Cognitively impaired individuals. Family members in families where only one person exhibits tune deafness. Individuals currently using psychoactive medication. |
Country | Name | City | State |
---|---|---|---|
United States | National Institutes of Health Clinical Center, 9000 Rockville Pike | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Institute on Deafness and Other Communication Disorders (NIDCD) |
United States,
Baharloo S, Johnston PA, Service SK, Gitschier J, Freimer NB. Absolute pitch: an approach for identification of genetic and nongenetic components. Am J Hum Genet. 1998 Feb;62(2):224-31. — View Citation
Profita J, Bidder TG. Perfect pitch. Am J Med Genet. 1988 Apr;29(4):763-71. — View Citation
Wightman FL, Green DM. The perception of pitch. Am Sci. 1974 Mar-Apr;62(2):208-15. — View Citation
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