Healthy Clinical Trial - Areas of Brain Responsible for NCT00001782

Clinical Trial Details — Status: Completed

Administrative data
NCT number	NCT00001782
Other study ID #	980082
Secondary ID	98-N-0082
Status	Completed
Phase	N/A
First received	November 3, 1999
Last updated	March 3, 2008
Start date	March 1998
Est. completion date	December 2000

Study information
Verified date	November 1999
Source	National Institutes of Health Clinical Center (CC)
Contact	n/a
Is FDA regulated	No
Health authority	United States: Federal Government
Study type	Observational

Clinical Trial Summary

The human brain is made up of two halves called hemispheres. Each half of the brain is responsible for processing different kinds of information. Previous neuroimaging studies have shown that both the right and left hemispheres are involved when processing information given in American Sign Language (ASL). However, the study also showed that when processing spoken language, the left hemisphere was mostly involved.

Researchers would like to find out more about how the brain processes American Sign Language (ASL). This study is designed to determine if the right hemisphere is necessary for normal understanding of ASL.

Description:

The purpose of this protocol is to determine if the right hemisphere activation associated with perception of American Sign Language (ASL) in deaf subjects and in normal hearing individuals raised by deaf parents (who learned ASL before written English) is necessary for appropriate understanding of ASL.

Recruitment information / eligibility
Status	Completed
Enrollment	30
Est. completion date	December 2000
Est. primary completion date
Accepts healthy volunteers	Accepts Healthy Volunteers
Gender	Both
Age group	N/A and older
Eligibility	Subject age between 18 and 65 years. Adult hearing offsprings of deaf parents. Congenitally deaf individuals. Intact hearing volunteers. No subjects with personal or family history of seizures or other neurological or demyelinating disorders. No pregnant women tested after urine pregnancy test. No subjects with severe coronary disease. No subjects with metal in the cranium except mouth. No subjects with intracardiac lines and implanted medication pumps. No subjects with increased intracranial pressure as evaluated by clinical means. No subjects with cardiac pacemakers. No subjects with an intake of neuroleptics.

Study Design

N/A

Related Conditions & MeSH terms

Locations
Country	Name	City	State
United States	National Institute of Neurological Disorders and Stroke (NINDS)	Bethesda	Maryland

Sponsors *(1)*
Lead Sponsor	Collaborator
National Institute of Neurological Disorders and Stroke (NINDS)

Country where clinical trial is conducted

United States,

References & Publications (2)

Cohen LG, Bandinelli S, Sato S, Kufta C, Hallett M. Attenuation in detection of somatosensory stimuli by transcranial magnetic stimulation. Electroencephalogr Clin Neurophysiol. 1991 Oct;81(5):366-76. — View Citation

Neville HJ, Bavelier D, Corina D, Rauschecker J, Karni A, Lalwani A, Braun A, Clark V, Jezzard P, Turner R. Cerebral organization for language in deaf and hearing subjects: biological constraints and effects of experience. Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):922-9. — View Citation

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Areas of Brain Responsible for Understanding American Sign Language

Clinical Trial Details — Status: Completed

Administrative data

Study information

Clinical Trial Summary

Description:

Recruitment information / eligibility

Study Design

Related Conditions & MeSH terms

Locations

Sponsors (1)

Country where clinical trial is conducted

References & Publications (2)