Healthy Clinical Trial
Official title:
Functional Neuroanatomy of Positive and Negative Affect in Alcoholics and Non-Alcoholics
This study was designed to learn more about the areas of the brain involved in the experience
of positive and negative emotions.
Patients who would like to participate in this study will first undergo a screening process
to see if they will be eligible for the study. Patients eligible to participate in the study
will go through two sessions.
During session one, researchers will attempt to evoke positive and negative emotions by
showing patients slides of different emotion-arousing stimuli (pictures of pleasant and
unpleasant scenes). While patients are viewing these slides, researchers will be measuring
patient's heart rate, sweating, and eye-blinking.
During session two, patients will undergo an MRI of the brain while seeing similar
emotion-arousing pictures as in session one. In addition, patients may be asked to play a
simple computer game for a reward of money while researchers use the MRI to measure brain
activity.
Researchers hope to develop methods to evoke positive and negative emotions and
simultaneously (at the same time) see brain activation in normal volunteers, alcoholics, and
recovered alcoholics.<TAB>
Objective: The purpose of this protocol is two-fold: 1) to determine how individual
differences in evoked brain responses relate to generalized trait personality and behavior
differences (as assessed by psychometric questionnaire instruments and behavioral measures),
and 2) to determine whether individual differences in evoked brain responses relate
specifically to genetic polymorphisms in genes governing neurotransmitter activity.
Study population: Healthy non-alcoholic adult volunteers, healthy adolescents aged 12 to 17
years (with or without a family history of alcohol use disorder), inpatient or outpatient
alcoholics, and recovering alcoholics.
Design: In this event-related functional magnetic resonance imaging (fMRI) study we will
attempt to evoke positive and negative affect via several different standardized methods
including: (1) pictures of emotion-arousing stimuli; (2) pictures of emotional facial
expression; (3) cues signaling reward or punishment. This protocol is designed to cover many
different functional magnetic imaging studies all using similar techniques to evoke and
measure positive and negative affect in the brain. Most subjects will not participate in
studies involving all the methods described in the protocol.
Outcome measures: The outcome measure is differences in blood oxygenation dependent level
(BOLD) signal measured using standard fMRI techniques and analyzed using AFNI software.
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