Healthy Clinical Trial
Official title:
Regional Cerebral Blood Flow Correlates of Spontaneous and Drug-Induced Clinical Changes in Mood Disorders
Positron Emission Tomography (PET) is a technique used to investigate the functional
activity of the brain. The PET technique allows doctors to study the normal biochemical and
metabolic processes of the central nervous system of normal individuals and patients with
neurologic illnesses without physical / structural damage to the brain.
When a region of the brain is active, it uses more fuel in the form of oxygen and sugar
(glucose). As the brain uses more fuel it produces more waste products, carbon dioxide and
water. Blood carries fuel to the brain and waste products away from the brain. As brain
activity increases blood flow to and from the area of activity increases also. Knowing these
facts, researchers can use radioactive chemicals (H215O) and PET scans to observe what areas
of the brain are receiving more blood flow.
Patients diagnosed with mood disorders and healthy volunteers will receive positron emission
tomographic (PET) scans with H215O while doing simple tasks. Patients will continue to
receive scans while in different mood states and while taking different medications.
Patients eligible for this study will be participating in other research studies measuring
other clinical and biochemical parameters (mood and anxiety ratings, medication responses,
and psychological test results). Information gathered from H215O PET scans measuring blood
flow to specific brain areas will be compared to the data gathered from other studies.
Objectives of this study are;
1. To determine differences in blood flow to the brain of patients with mood disorders
compared to healthy volunteers.
2. To determine differences in blood flow to the brain of patients with subtype mood
disorders (such as unipolar versus bipolar) compared to healthy volunteers.
2. To determine changes in blood flow to the brain of patients with mood disorders who
experience spontaneous changes in symptoms
3. To determine changes in blood flow to the brain of patients with mood disorders who
receive various kinds of therapy (medication, transcranial magnetic stimulation, etc.)
4. To determine if blood flow to specific areas of the brain can be used to predict how
patients will respond to certain types of therapy
5. To compare blood flow changes with various other clinical and biochemical parameters.
Patients with mood disorders and healthy volunteers will receive positron emission tomographic (PET) scans with H(2)(15)O to measure global and local differences in cerebral blood flow during a passive introspection task. Patients receive repeated scans while in different mood states and while participating in placebo controlled therapeutic trials as described by separate protocols. Global and regional cerebral blood flow is correlated with data obtained from participation in other protocols, which include clinical (life charting course of illness parameters, mood and anxiety ratings, medication response data, and psychological test performance) and biochemical (levels of medications, monoamines and peptides in the blood and cerebrospinal fluid) measures. ;
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