Healthy Clinical Trial
Official title:
Dose Response Relationship for Single Doses of Corticotropin Releasing Hormone (CRH) in Normal Volunteers and in Patients With Adrenal Insufficiency
Corticotropin Releasing Hormone (CRH) is a hypothalamic hormone made up of 41 amino acids.
Amino acids are proteins that when combined make up different substances, like hormones. The
order of amino acids in CRH, has been determined, meaning that the hormone can now be
synthetically reproduced in a laboratory setting.
When CRH is released from the hypothalamus it stimulates the pituitary gland to secrete
another hormone, ACTH. ACTH then causes the adrenal glands to make a third hormone,
cortisol. This process is known as the hypothalamic-pituitary-adrenal axis. Problems can
occur in any of the steps of this process and result in a variety of diseases (Cushing's
Syndrome and adrenal insufficiency).
Researchers hope that CRH created in a laboratory setting, ovine CRH (oCRH) can be used to
help diagnose and treat conditions of the HPA axis. This study will test the relationship
for single doses of oCRH in normal volunteers and patients with disorders of the HPA axis.
The oCRH will be injected into the patients vein as a single injection or slowly through an
IV line over 24 hours. The participants will have blood tests taken to measure hormone
levels before, during, and after receiving the oCRH.
Status | Completed |
Enrollment | 2250 |
Est. completion date | June 2005 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | N/A and older |
Eligibility |
INCLUSION CRITERIA: The normal volunteers are obtained through the NIH volunteer program or are NIH employees. Normal volunteers are in excellent health and are receiving no chronic medications. We now routinely test patients with hypocortisolism or hypercortisolism in our clinic and ward. |
N/A
Country | Name | City | State |
---|---|---|---|
United States | National Institute of Child Health and Human Development (NICHD) | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
United States,
Chrousos GP, Schuermeyer TH, Doppman J, Oldfield EH, Schulte HM, Gold PW, Loriaux DL. NIH conference. Clinical applications of corticotropin-releasing factor. Ann Intern Med. 1985 Mar;102(3):344-58. Review. — View Citation
Schulte HM, Chrousos GP, Booth JD, Oldfield EH, Gold PW, Cutler GB Jr, Loriaux DL. Corticotropin-releasing factor: pharmacokinetics in man. J Clin Endocrinol Metab. 1984 Jan;58(1):192-6. — View Citation
Schürmeyer TH, Avgerinos PC, Gold PW, Gallucci WT, Tomai TP, Cutler GB Jr, Loriaux DL, Chrousos GP. Human corticotropin-releasing factor in man: pharmacokinetic properties and dose-response of plasma adrenocorticotropin and cortisol secretion. J Clin Endocrinol Metab. 1984 Dec;59(6):1103-8. — View Citation
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