Neural Mechanisms of the Contextual Interference Effect: A fNIRs and EEG Study

Healthy Individuals Clinical Trial

— GRID12007  

Official title:

Neural Mechanisms of the Contextual Interference Effect: A fNIRs and EEG Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01134978
• Other study ID #: 16758
• Status: Completed
• Phase: Phase 1
• First received: May 27, 2010
• Last updated: November 4, 2011
• Start date: November 2007
• Est. completion date: June 2011

Study information

• Verified date: May 2011
• Source: Drexel University
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

The overall goal of this study is to gain insight into the neural mechanisms of learning multiple tasks. By examination of cognitive and behavioral output during the performance and learning of several computer maze tasks, and through a detailed examination of the neural activity obtained from functional near-infrared (fNIR) and electroencephalography (EEG), it may be possible to gain insight into the impact of the amount of practice and the organization of practice has on learning fine motor skills. This insight may provide direction as to how to better develop instructional and rehabilitation protocols in addition to clinical interventions to facilitate recovery of function, relearning and transfer of cognitive and fine motor skills based upon neural responses to physical practice.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: June 2011
• Est. primary completion date: December 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 55 Years

Eligibility

Inclusion Criteria:

• 18 to 55 years of age

• vision correctable to 20/20

• right-handed

• English is first language or learned English before age of 5 years

Exclusion Criteria:

• 17 years or younger and 56 years or older

• pregnant

• have latex or tape adhesives allergies

• self-exclude if:

• had a history of seizures, head injury or neurological dysfunction

• history or diagnosis of depression, schizophrenia or social phobia

• previous admission to alcohol/drug treatment program or diagnosis of alcohol/drug abuse

• take medications know to affect neurological function.

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Healthy Individuals
• Learning

Intervention

Behavioral:
• Practice Order
Blocked order - predictable Random order - unpredictable

Locations

Country	Name	City	State
United States	Cognitive Motor Movement Neuroscience Lab (CoMMoNS) - rm 3612 NCB, Drexel University	Philadelphia	Pennsylvania

Sponsors (2)

Lead Sponsor	Collaborator
Drexel University	Pennsylvania Department of Health

Country where clinical trial is conducted

United States, 

References & Publications (4)

Ayaz H, Shewokis PA, Curtin A, Izzetoglu M, Izzetoglu K, Onaral B. Using MazeSuite and functional near infrared spectroscopy to study learning in spatial navigation. J Vis Exp. 2011 Oct 8;(56). pii: 3443. doi: 10.3791/3443. — View Citation

Shewokis PA, Ayaz H, Izzetoglu K, Izzetoglu M, Bunce SC, Schultheis MT, Pourrezaei K. Dorsolateral prefrontal cortex activity during the learning of computer tasks in a contextual interference paradigm using fNIRs: a case series. Journal of Sport & Exerci

Shewokis PA, Ayaz H, Izzetoglu M, Bunce S, Gentili RJ, Sela I, Izzetoglu K, Onaral B. Brain in the Loop: Assessing Learning using fNIR in cognitive and motor tasks. D.D. Schmorrow and C.M. Fidopiastis (Eds.).Lecture Notes in Artificial Intelligence, 6780:

Shewokis PA, Ayaz H, Izzetoglu M, Getchell N, Izzetoglu K. the acquisition and learning of computer tasks in a contextual interference paradigm: Using functional near infrared spectroscopy to examine prefrontal cortex activity. Journal of Sport & Exercise

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	metabolic measures of neural activity in the dorsolateral prefrontal cortex	Functional near infrared spectroscopy (fNIR) uses specific wavelets of light, that are introduced at the scalp to measure changes in the relative ratios of deoxygenated hemoglobin and oxygenated hemoglobin in the capillary beds during brain activity.	outcomes measured 72 - 96 hours post-training	No
Secondary	Behavioral measures	maze behavioral responses of time to traverse the maze (sec), distance traveled (pixels)and average maze velocity (pixels/sec) are calculated.	measured 72-96 hours post training	No