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Healthy Individuals clinical trials

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NCT ID: NCT01835717 Completed - Healthy Individuals Clinical Trials

Study for Cognitive and Genetic Characterization of a 45-65 Years Old Population

Start date: April 2013
Phase:
Study type: Observational

Before Alzheimer's disease (AD) clinical symptoms appear, there is a long period when changes in the brain occur. In this long asymptomatic period or preclinical phase, studies with populations at risk of developing AD have shown cognitive differences compared to control groups without such risk. There is a need for short, sensitive, easily administered, reproducible, non-expensive and independent of socio-demographic influences tests enabling the detection of pre-symptomatic variations in memory, when the memory decline is still within a normal range. Study main hypothesis: When evaluated with high-demanding tests of memory and executive function, the cognitive performance of cognitive healthy people aged between 45 and 65 and, extensively, to a group of up to 75 years, will vary significantly depending on clinical, socio-demographic and genetic features

NCT ID: NCT01721811 Recruiting - Healthy Individuals Clinical Trials

Retinal Function in Relation to Transient or Chronic Challenges to Retinal Metabolism

Start date: October 2012
Phase: N/A
Study type: Interventional

The aim of the study is to investigate how the retina adapts to different metabolic challenges, e.g. chronic systemic hypoxia, hyperglycemia, special training conditions or diets as well as transient changes in the content of oxygen and glucose in the blood.

NCT ID: NCT01568541 Completed - Healthy Individuals Clinical Trials

Fluoride Intake From Toothbrushig With Children's or Regular Toothpastes

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Start date: October 2007
Phase: N/A
Study type: Interventional

There are controversial data about fluoride intake by children when tooth brushing with children's or regular toothpastes. However, a study have showed that children were exposed to a dose of 0.051 mg F/Kg/day and 0.046 mg F/kg/day by tooth brushing with children's and and regular toothpaste, respectively. Fluorides doses were too close and is questioned if there is a real clinical relevance in terms of risk of dental fluorosis. It is important to evaluate if children's toothpastes does really represent a risk of fluoride intake when compared to the regular toothpastes in terms of risk of dental fluorosis. The hypothesis is that both children's and regular toothpastes can represente risks of development of dental fluorosis and can represent similar fluoride exposure by children.

NCT ID: NCT01545973 Suspended - Healthy Individuals Clinical Trials

Understanding the Physiological Implications of Scanning Kelvin Probe Measurements

Start date: August 2011
Phase: N/A
Study type: Observational

The purpose of this study is to evaluate the effects of skin thickness, skin moisture, and sweat gland density on Scanning Kelvin Probe measurements.

NCT ID: NCT01545960 Suspended - Healthy Individuals Clinical Trials

Evaluating Acupuncture Points With Scanning Kelvin Probe

Start date: August 2011
Phase: N/A
Study type: Observational

The purpose of this study is to characterize the surface electrical potential of acupuncture points with a Scanning Kelvin Probe.

NCT ID: NCT01512316 Withdrawn - Healthy Individuals Clinical Trials

Exploring Learning and Unlearning of Fear

Start date: n/a
Phase: N/A
Study type: Interventional

The present study investigates the effect of d-cycloserine on learning and unlearning of fear in healthy humans and its underlying effect on the amygdala. As a second objective, the effect of genotype on fear learning will be studied.

NCT ID: NCT01320969 Completed - Healthy Individuals Clinical Trials

Could Meditation Modulate the Neurobiology of Learning Not to Fear?

Start date: December 2010
Phase: N/A
Study type: Interventional

It is well-established that the practice of mindfulness meditation leads to improvements in mental health and well-being and the cultivation of positive emotions. However, the neural mechanisms of these improvements are largely unknown. A few recent studies suggest that mindfulness meditation impacts the structure and function of the ventromedial prefrontal cortex, the hippocampus, and the amygdala. Interestingly, recent studies have shown that these regions are part of a brain circuit that is critical for the extinction of conditioned fear responses, and for the retention of fear extinction memory. Building on the overlap of these regions and on conceptual considerations, the project investigates whether mindfulness meditation could influence one's capacity to retain the memory of fear extinction. Meditation-naïve participants will be randomized to either a mindfulness-meditation based training or an active control training that controls for all mindfulness-unspecific components. Participants will undergo a fear conditioning, extinction and extinction recall protocol in an MRI scanner before and after the trainings. We hypothesize that participants who have practiced mindfulness meditation will show greater improvements in fear extinction memory after the course, and that these improvements will be correlated with anatomical and functional changes in the brain regions of interest. Improvements in fear extinction memory will also be related to improvements in self-reported psychological well-being. Merging the fields of an ancient spiritual tradition and a fundamental learning mechanism, the project investigates the underlying neural mechanisms of a practice for the enhancement of mental health and well-being.

NCT ID: NCT01259570 Not yet recruiting - Healthy Individuals Clinical Trials

Bioavailability of Vitamin D Encapsulated in Casein Micelles, Compared to Its Bioavailability in the Milk-fat, or in a Synthetic Emulsifier Currently Used for Supplementation and Enrichment

Start date: January 2011
Phase: N/A
Study type: Interventional

The encapsulation within CM may improve bioavailability (BA) of vitamin D (VD), even in absence of fat. As a model the investigators have chosen nonfat yoghurt. The investigators will prepare yoghurts from 4 milks: (1) Skimmilk enriched with 50,000 IU/150gr VD encapsulated in CM2 ; (2) 3% fat milk wherein same dose of VD - dissolved in milk fat and homogenized into skimmilk; (3) 3% fat milk wherein VD, at same dose, will be in CM; (4) Placebo: unenriched skimmilk. 120 healthy adults aged 18-65 will randomized to 5 groups and receive 150 gr yoghurt. Blood will be drawn before ingestion and on days 1,7,14. 25(OH)D will be det. by CMIA. In vitro simulated digestion will be studied. Expected results: The BA of VD in CM would not be lower than in fat

NCT ID: NCT01211717 Completed - Type 2 Diabetes Clinical Trials

The Effects of Orally Ingesting Branched Chained Amino Acids on Delayed Onset Muscle Soreness in Diabetic Patients

Start date: October 2010
Phase: N/A
Study type: Interventional

The purpose of this study is to determine the effectiveness of the 3 Branched Chained Amino Acids (isoleucine, leucine, and valine) on treating Delayed Onset Muscle Soreness, a type of muscle pain which usually develops after exercising.

NCT ID: NCT01168102 Completed - Healthy Individuals Clinical Trials

Noninvasive Blood Ethanol Measurement With Infrared Spectroscopy

Start date: March 2007
Phase: N/A
Study type: Observational

The objective of this study is to assess the performance of a noninvasive device for the detection of blood alcohol levels.